Hartshorne taught English literature at the
Friends' School in Tokyo in the 1890s. She helped raise funds to open the Joshi Eigaku Juku (Women's Institute of English Studies) in 1900, which was forerunner of Tsuda University. She taught at the Tsuda school from 1902 until 1940, as a volunteer. When the
1923 Great Kantō earthquake destroyed the school's campus, she toured in the United States to raise money to rebuild it, and oversaw the rebuilding after Tsuda Umeko's death in 1930. She reported on the school's reopening on another visit to the United States in 1937. Hartshorne wrote
Japan and Her People (1902, 2 vol.) and
A Reading Journey Through Japan (1904). She also designed the American cover of
Nitobe Inazō's
Bushido: The Soul of Japan (1900). == Personal life ==