Her first marriage was to the
sebastokratōr Isaac Komnenos Vatatzes, a great-nephew of the emperor
Manuel I Komnenos. They had one daughter,
Theodora Angelina. Soon after Anna's father became emperor, in 1195, Isaac Komnenos was dispatched to combat the
Uprising of Asen and Peter. He was captured, became a pawn between rival Bulgarian and Vlach factions, and died while imprisoned. Theodora, the young daughter of Anna, was betrothed to the Bulgarian boyar
Ivanko with the blessings of her grandfather Alexios III, who considered Ivanko a worthy potential son-in-law. However, the emperor postponed the marriage for a more suitable time, as Theodora still spoke like a child. According to the historian Niketas Choniates, Ivanko, noticing that his betrothed was very young, “
fixed his gaze upon her rosy-cheeked mother,” Anna, who was then a widow. Allegedly envisioning a more splendid union, he is said to have told the emperor: "
Why give me a little lamb, when I seek a full-grown goat?" Nevertheless, the imperial family did not agree to this proposal. Her second marriage to
Theodore Laskaris, future emperor of
Nicaea, was celebrated in a double wedding in late 1199/early 1200 (the other couple was Anna's sister Irene and
Alexios Palaiologos). The armies of the
Fourth Crusade reached to Constantinople in 1203. Following the flight of Alexios III and the accession of
Alexios IV Angelos to the throne (along his father
Isaac II Angelos) with the support of the Crusaders, Theodore Laskaris was captured and imprisoned due to his status as the son-in-law of Alexios III. His wife, Anna, and his mother-in-law, Euphrosyne Doukaina Kamatera, were also detained. However, in the autumn of 1203, Theodore, together with Anna and their three daughters, managed to escape to Asia Minor, reaching Bithynia by passing through the Frankish encampment. In 1205, Theodore Laskaris became emperor of Nicaea. At the begging of Theodore's campaign in Asia Minor the inhabitants of Nicaea initially refused to accept Laskaris as their overlord. Instead he proposed that they receive only Anna. In this way, Anna would effectively become a hostage, serving as a demonstration of Laskaris’s good intentions. Eventually, the city of Nicaea did open its gates to Theodore, a decision that was likely influenced by the diplomatic efforts of Princess Anna during her time within the city. According to
George Akropolites, the Seljuk Sultan
Kaykhusraw regarded Anna as his sister. This perceived sibling relationship likely stemmed from his baptism in Constantinople by Emperor Alexios III, which created a spiritual bond between Kaykhusraw and the daughters of Alexios. As a result, Anna played a significant role in forging an early alliance between Theodore I Laskaris and the Seljuk Sultan at a critical moment for the consolidation and survival of the Nicaean state. An alliance that lasted until 1210. In the spring of 1208, following deliberations with the Empire of Nicaea, a supplicatory letter (
deetērion) was sent by the inhabitants of Constantinople to Theodore I Laskaris. In this petition, the Constantinopolitans addressed Laskaris and expressed their recognition of his authority. A similar letter was sent simultaneously to Anna Angelina, whom they referred to as
Augusta and daughter of Alexios III. Around 1208- 1209, Theodore Laskaris ordered that all subjects of his realm swear an oath of allegiance to his authority and to the imperial family. The Church of Nicaea, led by Patriarch
Michael IV Autoreianos, committed itself through a formal decree (
tomos), proclaiming its loyalty to Emperor Theodore and his son, Nicholas Laskaris. The decree also explicitly affirmed allegiance to Empress Anna, whom it referred to as
Kyria and
Despoina (lady and mistress). While in rhetorical texts, she is referred to as the Holy Lady
(Hagia Despoina). Following the suicide of
Leo Sgouros at Acrocorinth around 1207/1208, Anna offered asylum to her sister
Eudokia Angelina, who fled to Asia Minor. Anna Angelina Komnene died in 1212. ==Issue==