Mancuso is an Italian surname derived from a Sicilian noun, related to the Italian mancino, which means "left-handed". An alternate form can be Mancusi. Notable people with the surname include:Adolfo Mancuso, Argentine swimmer Alejandro Mancuso, Argentine footballer Anna Mancuso, Canadian politician Ciro Mancuso, Nevada-based drug dealer convicted of running a $140-million marijuana smuggling operation David Mancuso (1944–2016), American DJ Eros Mancuso, Argentine footballer Filippo Mancuso (1922–2011), Italian judge and politician Francis Xavier Mancuso (1887–1970), leader of Tammany Hall and judge for New York's Court of General Sessions Frank Mancuso Jr., movie producer Gianluca Mancuso, Argentine footballer Gus Mancuso (1905–1984), catcher in Major League Baseball from 1928 to 1945 Julia Mancuso, American alpine skier who won a gold medal at the 2006 Winter Olympics Laurence Mancuso (1934–2007), founding abbot of the New Skete monastery Leonardo Mancuso, Italian footballer Matteo Mancuso, Italian jazz and rock guitarist and composer Nick Mancuso, Italian-Canadian cinema and stage actor Renee Mancuso, American bridge player Rudy Mancuso, American actor and Internet personality and musician Salvatore Mancuso, Colombian paramilitary warlord Stefano Mancuso, Italian botanist and writer