She was a daughter of Duke
Magnus II of Mecklenburg (1441–1503), and
Sophie of Pomerania-Stettin (about 1460 – 1504). She was a member of the 13th Generation of the Princely
House of Mecklenburg. In 1500, Anna married
William II of Hesse (1469–1509). She was his second wife. Due to the early death of the ruler of Upper Hesse,
William III (1471–1500), and the insanity of the Regent of
Lower Hesse,
William I (1466–1515), all of Hesse, including the
county of Katzenelnbogen, was reunited in 1500 under William II. But Wilhelm II fell ill in 1504 – probably
syphilis – and was incapable of governing in the following years. In his first will (dated 1506), he appointed a Council of five guardians for his children
Elisabeth (1502–1557) and
Philip I (1504–1567) as well as his brother William I, his brother's wife Anna of Brunswick, and for his own wife. In his second testament (dated 1508), he determined, however, that Anna would be guardian (next to his uncle, Hermann of Cologne, who died in September 1508) and appointed two counselors to assist her. In 1509, Wilhelm II died. However, Anna's claim to the regency was not recognized by the Estates of the Landgraviate of Hesse, nor by Saxony. In July 1509 there was a debate between Anna and the Hessian Estates, who were supported by the Saxon dukes. The second will was not recognized. During this period Anna lived at her
Wittum in
Gießen with her daughter Elisabeth, while her son Philip remained in
Kassel under the supervision of Ludwig von Boyneburg to Lengsfeld. She was financially dependent on the Council and did not receive much money. This is evident among other things, an incident in 1512. In that year, Anna's sister
Catherine married Duke
Henry IV of Saxony. On this occasion, Anna wanted to introduce her daughter Elisabeth at the Saxon court, as she had been promised at a very early age to
John, the eldest son of
George the Bearded. Anna requested some
damask for a proper dress from the council, but the request was denied. Anna then decided not to take her daughter to
Dresden, because of her "shabby clothes". Things changed in 1514. Anna came to power with the support of many nobles and cities. She was never officially recognized as a regent, but she ruled even past 1519, the year her son Philip was declared of age by Emperor
Maximilian I. Very little is known about the last years of her life. In 1519 she married a second time, with the 23-year-old Count Otto of Solms-Laubach, who died three years later. == Offspring ==