Beginning in 2007, while still an undergraduate at Makerere University, Kansiime began to participate in drama skits acted by the theatre group
Theatre Factory, who played at the
Uganda National Theatre in
Kampala's central business district. When Theatre Factory disintegrated, she joined
Fun Factory, that replaced it. The group plays every Thursday evening. The best skits were broadcast on NTV Uganda in the
Barbed Wire TV show that later became
U-Turn. She partnered with Brian Mulondo as a Taxi interview conductor in the
MiniBuzz series and provided comic video dramatizations of topical issues that random passengers discussed. According to recorded interviews that she gave in 2014, Anne began posting some of her sketch comedy skits on YouTube. She received positive feedback and that encouraged her to post more videos. Her screen breakthrough came when
Citizen TV from neighboring
Kenya offered her a slot to produce, star and present a comedy show once a week. That is how she came up with the
Don't Mess With Kansiime comedy show. As of November 2014, her YouTube channel had amassed more than 15 million views. Her YouTube videos receive thousands of views and she has appeared on BBC Focus on Africa. She has played to packed houses in
Blantyre,
Gaborone,
Kigali,
Kuala Lumpur,
Lagos,
Lilongwe,
London,
Lusaka and
Harare. ==Other considerations==