Early career Cacace made his professional debut on 25 February 2012, scoring a first-round
technical knockout (TKO) victory over Ben Wager at the Emerald Roadhouse in
Belfast, Northern Ireland. Followed three more wins—a
points decision (PTS) over
Kristian Laight in April; a sixth-round TKO over Mickey Coveney in July; and Aivaras Balsys by PTS in September—Cacace fought Mickey Coveney for a second time on 3 November 2012 at the
National Basketball Arena in
Dublin. Cacace won via first-round TKO to capture the
BUI super-featherweight title. His final fight of 2012 was a PTS victory against Youssef al-Hamidi in December. He gained decision victories over Zsolt Nagy in March and Osnel Charles in October 2013, followed by wins over Dawid Knade by TKO in September and Simas Volosinas by PTS in December 2014. He began 2015 with a PTS win over Santiago Bustos in February and a TKO win against Karoly Lakatos in June. His last fight of 2015 was against Ronnie Clark for the vacant Celtic super-featherweight title. The bout took place on 16 October at the
Meadowbank Sports Centre in
Edinburgh. Cacace captured the Celtic title via tenth-round TKO in a scheduled ten-round fight. Following two fights in 2016 — a
corner retirement (RTD) win against Jamie Quinn in September and a PTS win over Leonel Hernandez in November—Cacace challenged
British super-featherweight champion
Martin J Ward on 15 July 2017, at the
Wembley Arena in
London, with the vacant
Commonwealth title also on the line. In what was a close competitive fight, Cacace suffered the first defeat of his professional career, losing by
unanimous decision (UD) over twelve rounds, with the judges' scorecards reading 116–113, 116–114 and 115–113, all in favour of Ward. Following his defeat to Ward, Cacace gained a PTS victory over six rounds against Reynaldo Mora in December 2017. After 14 months out of the ring, Cacace was back in action in February 2019 with an eight-round PTS win over Alan Castillo. Cacace, as the mandatory contender, was due to challenge for the British super-featherweight title on 3 August 2019 against reigning champion
Sam Bowen, however, Bowen pulled out of the fight due to a back injury. The bout was rescheduled for 30 November at
Arena Birmingham. Cacace won, capturing the British title via
split decision (SD), with two judges scoring the bout 115–113 to Cacace while the third scored it 115–112 to Bowen. Cacace won the
IBO super-featherweight title by defeating
Michael Magnesi via split decision at
Manchester Arena on 24 September 2022.
IBF Super featherweight champion Cacace vs. Cordina On 18 May 2024, Cacace challenged then unbeaten champion
Joe Cordina for the
IBF super-featherweight title on the undercard of
Tyson Fury vs. Oleksandr Usyk. After dropping and badly hurting Cordina in round three, Cacace continued to pour on the pressure and ended up scoring an eighth round technical knockout win. This made him the first Irish super-featherweight champion.
Cacace vs. Warrington Cacace defeated two-time former featherweight world champion
Josh Warrington by unanimous decision at
Wembley Stadium on 21 September 2024. The three ringside judges scored the fight 118–110, 117–111, 117–111 respectively in his favour. Cacace's belt was not on the line as the IBF did not recognise Warrington as a challenger due to his inactivity in the super-featherweight division, with the governing body announcing he would be stripped of the title had he lost the contest.
Vacating title Cacace vacated the IBF title on 31 January 2025. In a social media post announcing the decision he said: "Becoming a world champion was an absolute dream and an incredibly proud moment for me. However, at this stage of my career, I only want the biggest fights possible, regardless of the belt on the line."
Cacace vs. Wood Cacace successfully defended his IBO title by stopping
Leigh Wood in the ninth round of their bout at
Nottingham Arena on 10 May 2025.
WBA super-featherweight title challenge Cacace vs. Dickens Cacace challenged
WBA super-featherweight champion
Jazza Dickens at
3Arena in Dublin on 14 March 2026. He won by unanimous decision. ==Professional boxing record==