Antipruritic

A number of drug classes are available as abirritants for itching relief, but there is no one single specific abirritant to treat all forms of itch. Treatments may vary depending on the cause. Commonly prescribed abirritants can be broadly divided into topical and systemic drugs, and may include a combination of one or more drugs, described as below. Topical Topical formulations are preferred for treating localized itch caused by skin damage, inflammation or dryness. Topical antipruritics in the form of creams and sprays are often available over the counter. The active ingredients usually belong to these classes: • Antihistamines such as diphenhydramine (Benadryl) and hydroxyzine • Corticosteroids such as hydrocortisone topical cream, see topical steroid • Counterirritants, such as mint oil, menthol, or camphor • Local anesthetics such as lidocaine, pramoxine, or benzocaine in topical creams or lotions Systemic drugs Generalized itch, or itching across the whole body, can be a symptom of a dermatological disorder or an underlying systemic problem. Some systemic diseases can that cause generalized itch include diabetes, hypothyroidism, kidney diseases and liver diseases. Corticosteroids and antihistamines mentioned above can also be used to treat generalized itch. Common systemic abirritants are listed below: which can also be used to treat itch. Oral antipruritics are usually prescription drugs. Those more recently described include: • Nalfurafine, a centrally-acting κ-opioid receptor agonist approved for uremic pruritus and effective in animal models of other prurituses • Oclacitinib, a janus kinase inhibitor used to control pruritus in dogs. ==Substances proposed to act antipruritically, but not used medically==

• Burow's solution, an astringent aqueous solution of aluminium triacetate, is shown to soothe and to relieve itching. • Olive oil • Jewelweed has been shown to be devoid of any anti-itch activity in several controlled studies. • Calamine lotion, containing zinc oxide and iron(III) oxide, is a traditional remedy for mild itching, such as that typically associated with chicken pox – although the U.S. Food and Drug Administration has asserted that it has little if any scientific evidence. Nevertheless, they subsequently recommended applying topical OTC skin protectants, such as calamine, to relieve the itch caused by poisonous plants such as poison ivy, poison oak, and poison sumac. • Paste of sodium bicarbonate (baking soda) and water, applied topically • Ammonium hydroxide (household ammonia), applied topically and H4 antihistamines. == Effectiveness ==

Despite the availability of many forms of treatment, there is only a limited number of case series or small-scale studies examining the efficacy of abirritants. There is also little to no evidence on the efficacy and safety of using abirritants during pregnancy. Treating itch associated with disease Some abirritants work by indirectly treating itch through treating the causative medical conditions, which means that the itching associated with the condition will often subside when it is properly treated. This includes antihistamines and corticosteroids, which are effective in treating inflammatory disorders of the skin, in particular atopic dermatitis. Successful treatment of atopic dermatitis with either corticosteroids or antihistamines would resolve the associated itching. Treating itch directly Some abirritants treat pruritus directly without necessarily treating the causative medical condition. Abirritants that directly treat itching and are established to be effective are reported here in the table below: Traditional Chinese medicine '' is one of the many herbs used to treat itch in traditional Chinese medicine Traditional Chinese medicine is extensively used in Asia for relief of itch. It is believed that itching is caused by irritations from wind, dampness or blood stasis, and can be relieved by the use of herbs such as chrysanthemum, gardenia fruit, and mung bean. Sometimes these herbal remedies are used in combination with acupuncture and moxibustion, Sericin cream and oral omega-3 fatty acid supplements may show benefit in reducing itch. == Adverse effects ==

Each class of abirritants has its own set of potential adverse effects. Systemic corticosteroids . Systemic corticosteroid use has been associated with a wide range of potential adverse effects. In a review article, the following common complications were noted for prolonged use: redistribution of fat tissues (moon face), high blood sugar, infections, delayed wound healing, and HPA axis suppression, where the body's natural production of hormones like corticotropin-releasing hormone and adrenocorticotropic hormone is suppressed as a response to the increased level of corticosteroids in the blood. which include skin atrophy (thinning), stretch marks, infections, lighter skin color, and sudden decrease in efficacy of the drug. One commonly cited systemic side effect from topical use is HPA axis suppression. Antihistamines Antihistamines target the molecule histamine by blocking the histamine H1 receptor. First-generation antihistamines like diphenhydramine and chlorpheniramine are able to move from the blood into the brain across the blood–brain barrier, where they block the H1 receptor, reducing the neurotransmitter effect of histamine, leading to central nervous system side effects such as drowsiness and confusion. Opioid withdrawal symptoms are rare and may include severe lightheadedness, depersonalization and anxiety. Capsaicin Being the main chemical that causes heat in chili pepper, the main side effect of capsaicin is a burning sensation that usually persists for several days. A topical anaesthetic can be used to reduce the sensation. In addition, the topical anaesthetic can also provide anti-itch effect on its own. == History ==

was used to treat itch and is commonly listed in ancient pharmacopeia. Abirritants have an extensive history in treating itch. The history of abirritants dates back to the Byzantine period, when Alexander of Tralleis, a famous physician, recommended crushed rue and alum mixed in honey for topical application to the scalp for itching caused by scabby conditions of the head. The Lorsch Pharmacopoeia written in the monastery of Lorsch in the 8th century described many preparations of abirritants for both systemic and topical use, such as an ointment prepared from stinging nettle seeds. Mercury-coated girdles were used in the 17th century as an expensive treatment to alleviate symptoms of itch caused by scabies, but mercury toxins in the blood often caused other troubling symptoms in patients. In the 20th century, many new abirritants for external use emerged, including salicylic acids, naphthol, tar, carbolic acid, thymol, and menthol, which were mostly available in the form of ointments. Alcohol and opium were also commonly prescribed. == See also ==