The Catechetical School of Antioch was one of the two major Christian centers of the study of biblical exegesis and theology during Late Antiquity; the other was the School of Alexandria. This group was known by this name because the advocates of this tradition were based in the city of Antioch in Roman Syria, one of the major cities of the ancient Roman Empire. Although there were early interpreters from Antioch, like Theophilus of Antioch, the proper school of exegesis at Antioch belongs to the period of the 4th and 5th centuries.