Papadopoulos began his career with
VfR Aalen in 2017, and transferred to
Hallescher FC in 2019. In 2021, he transferred to the
Borussia Dortmund reserves. He appeared for the senior
Borussia Dortmund team in a 3–0
DFB-Pokal win over
SV Wehen Wiesbaden on 7 August 2021. A week later, on 14 August, he made his
Bundesliga debut in a 5–2 victory over
Eintracht Frankfurt. In August 2022, he extended his contract with Borussia Dortmund until 2024. Later that year, on 5 October, he played his first
UEFA Champions League match which ended in a 4–1 away victory over
Sevilla. On 4 May 2024, he made his first Bundesliga start in a 5–1 victory over
FC Augsburg. On 5 June 2024, Papadopoulos signed a three-year contract with
Lugano in Switzerland. ==Personal life==