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APEX1
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APEX1
DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.
Interactions
APEX1 has been shown to
interact
with
MUTYH
,
Flap structure-specific endonuclease 1
and
XRCC1
. ==Aging==
Aging
Deficiency of APEX1 causes accummulation of
DNA damage
leading to both
cellular senescence
and features of premature
aging
. This finding is consistent with the theory that DNA damage is a primary cause of aging. == References ==
Source: Wikipedia ↗
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