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APEX1

DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene.

Interactions
APEX1 has been shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1. ==Aging==
Aging
Deficiency of APEX1 causes accummulation of DNA damage leading to both cellular senescence and features of premature aging. This finding is consistent with the theory that DNA damage is a primary cause of aging. == References ==
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