Agnihotri debuted in the film Pardes, co-starring with Shahrukh Khan and directed by Subhash Ghai. The film was highly successful and garnered Agnihotri the nomination for Best Supporting Actor in Zee Cine Awards. After several more film roles, he was offered the lead role in Jassi Jaissi Koi Nahin, an Indian television serial. His work as Armaan Suri won him the Indian Telly Awards Best Actor Award for 2005. He participated in Colors TV's Bigg Boss 7 on 15 September 2013 with his wife Shilpa Saklani. He went on to play roles in shows like Pyaar Ka Dard Hai Meetha Meetha Pyaara Pyaara, Ajeeb Dastaan Hai Yeh and SauBhagyalaxmi. In 2018, he joined Bepannah as Rajveer Khanna. He then portrayed Harry Somani in ALT Balaji's Kehne Ko Humsafar Hain for three seasons. Since December 2025, he played Dr. Fareed Quadri in Colors TV's Seher - Hone Ko Hai.{{Cite news|last=Sehgal|first=Chirag|date=25 October 2025 |title=Apurva Agnihotri To Play Dr Farid In Upcoming Television Show Seher Hone Ko Hai ==Filmography==