Aranthangi Nisha made her television debut in 2015 on the
Vijay TV's' comedy reality show
Kalakka Povathu Yaaru? as a contestant. She successfully emerged as the 1st runner up of the show and received positive feedback for her talent in the show. After her appearance in the show she started to appear in films. She made her debut in the film
Maari 2 in 2018 alongside actors
Dhanush and
Sai Pallavi playing the role as Attu Aanandi which received an overall positive reviews from critics and viewers who praised Nisha for her role in the film. She later appeared in various different films such as
Irumbu Thirai (2018),
Kolamaavu Kokila (2018) and
Seemaraja (2018). She later returned to television hosted a various number of shows such as
Mr and Mrs Chinnathirai (season 1) in 2019 and
Cooku with Comali in 2020. Later in 2020, she appeared in the reality show
Bigg Boss Tamil (season 4) as a contestant and was later evicted from the show on the 70th day. After her Bigg Boss experience she returned to films and acted in films like
Hostel (2022),
Thiruchitrambalam (2022) and
Trigger (2022). She appeared in the film
Aneethi directed by
Vasanthabalan, alongside actors
Arjun Das and
Dushara Vijayan. ==Social work==