After receiving her PhD, she went to
Washington, D.C., on a 1984 to 1986 congressional fellowship with the
Office of Technology Assessment. She was then the vice president and later president of
Interval Research from 1998 to 2000. Prabhakar was a Fellow at the
Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford 2017–18. In 2019, she started Actuate, a nonprofit organization focused on issues including climate change and chronic diseases.
Biden Administration In 2022, Prabhakar was appointed by President
Joe Biden as Director of the
White House Office of Science and Technology Policy (OSTP) and Science and Technology Advisor to the President, and the first woman and first person of color to be the top science and technology advisor to the President. Prabhakar was among Biden's top advisors on matters regarding
artificial intelligence (AI) regulation, where she has endorsed AI safeguards. Under her leadership, OSTP contributed to improving health outcomes with the Biden Cancer Moonshot, promoting research and strategies to address climate and nature, and strengthening federally funded research and development.
Amicus brief On July 25, 2025, Prabhakar filed an amicus brief in the case of
New York v. Trump (25–1236 and 25-1314), the case brought by 23 attorneys general and the governor of Kentucky against the Trump administration’s federal funding freezes and grant cancellations. Many of the plaintiffs and amicus filers challenged the authority of the president to redirect Congressionally appropriated funds. Prabhakar’s brief details the lasting harms that the freeze will have on the efforts of scientific researchers who innovate for the nation’s health, security, and economy. It further warns that the freeze has created lasting damage to the United States’ status as a leader in scientific innovation, weakening the nation’s pipeline of scientists and engineers and depriving Americans of future scientific advancements. ==Awards and memberships==