ARHGEF7

βPIX is a multidomain protein that functions both as a signaling scaffold protein and as an enzyme. βPIX shares this domain structure and signaling function with the highly similar ARHGEF6/αPIX protein. βPIX undergoes extensive alternative splicing to generate multiple variant proteins containing or lacking particular protein domains. scribble, and SNX27 proteins. Some splice variants of βPIX contain an amino-terminal Calponin Homology (CH) domain whose functions remain relatively poorly defined, but may interacts with parvin/affixin family proteins. βPIX variants with this extended amino terminal CH domain are most highly expressed early in development, but appear rare after birth. == Interactions ==

βPIX has been reported to interact with over 120 proteins. Major interacting proteins include: • Itself, or the highly-related ARHGEF6/αPIX via a trimeric coiled-coil interaction. • GIT1 or GIT2 dimers via GIT-binding domain. • p21-activated kinases (PAKs) 1, 2 and 3 via SH3 domain. • c-Cbl via SH3 domain. • Rho family GTP-binding protein family members Rac1 and Cdc42, activated via DHPH RhoGEF domain. • The neuronal synapse adaptors SHANK1, SHANK2, and SHANK3 via PDZ • Scribble via PDZ • SNX27 via PDZ == See also ==