Aristobulus III was the last scion of the Hasmonean royal house, brother of Herod the Great's wife Mariamne, and grandson of Hyrcanus II and Aristobulus II. He was a favourite of the people on account of his noble descent and handsome presence, and thus became an object of fear to Herod, who at first sought to ignore him entirely by debarring him from the high priesthood. But his mother Alexandra, through intercession with Cleopatra and Mark Antony, compelled Herod to remove Ananelus from the office of high priest and appoint Aristobulus instead.