The route begins at
Arkansas Highway 235 near
Bruno and runs north past the historic
Eros School Building to intersect
US 62/
US 412 in
Pyatt. The routes become
concurrent until
George's Creek, near the George's Creek Cemetery. Highway 125 winds north through farms and trees until forming a concurrency with
Highway 14 near
Lakeway. Highway 14 turns west north of Lakeway, with Highway 125 continuing north through
Peel. Highway 125 crosses the Lake on the Peel Ferry, a free ferry and the only ferry in the Arkansas state highway system. Now on the west side of the Lake, Highway 125 runs north to the
Missouri state line, where it continues as
Missouri Route 125. ==Peel Ferry==