As a former
U.S. Route, the route passes through many historic districts and has many junctions. The route begins at
US 65B/
US 79B in northwest
Pine Bluff near the
University of Arkansas at Pine Bluff and runs northwest. Highway 365 is known as Dollarway Road in this part of Pine Bluff as it follows the original routing of the Dollarway Road, a 1913 paving project that gave Jefferson County the longest continuous concrete road in the nation at the time. Upon entering Pulaski County, Highway 365 passes through Hensley,
Woodson,
Wrightsville and
Tafton before passing the
Hanger Cotton Gin at
Sweet Home. The route next enters
Little Rock where it junctions with
I-440 before becoming turning west onto Roosevelt Road. Highway 365 passes
Little Rock National Cemetery before intersecting
I-30/US 65/
US 67/
US 167 at a
frontage road interchange. Roosevelt Road serves Main Street before forming a northbound concurrency with
US 70 along Broadway Street. This segment of road passes many historic properties in addition to
I-630. Highway 365 crosses over the
Arkansas River into
North Little Rock and breaks from US 70 to the west near
Dickey-Stephens Park. Highway 365 passes over the railyard, intersecting Riverfront Drive and becoming Pike Avenue to the north. Highway 365 intersects
Interstate 40/US 65 before passing
Camp Robinson. The route runs along I-40/US 65 until crossing over near
Maumelle. After a junction with
Highway 100, Highway 365 continues north along the Arkansas River into
Faulkner County. The highway intersects I-40/US 65 and
Highway 89 in
Mayflower near
Lake Conway. Highway 365 continues along I-40/US 65 into south
Conway where it terminates at
US 65B and
Highway 60. ==Major intersections==