Hartford to Fort Smith Highway 45 begins at
Highway 96 in
Hartford and runs north to meet
Highway 252 on either side of
Midland. Further north, the route has a concurrency with
Highway 10 through downtown
Hackett. Slightly north of Highway 10, Highway 45 runs on the
Hackett Creek Bridge and continues north to
Bonanza. The route intersects
Highway 253 and curves east to form a concurrency with
US 71. The highway splits from US 71 to the north, entering
Fort Smith, and intersects
Highway 255 before terminating at
I-540/US 71. The route continues northeast through
Clyde before passing the
Pyeatte Mill Site and entering the historic community of
Canehill. Continuing north, the highway meets
US 62 east of
Lincoln, where it terminates.
Fayetteville to Clifty The route begins at College Avenue and runs west as Lafayette Street through
Fayetteville. Highway 45 runs through the
Washington-Willow Historic District before a sharp left turn onto Mission Boulevard. The highway continues northeast until intersecting
Highway 265 and exiting Fayetteville heading east. Passing the
Son's Chapel and entering
Goshen, the highway continues east through rural Washington County until entering
Madison County shortly after a junction with
Highway 303. Highway 45 has a junction with
Highway 295 before forming a concurrency with
US 412B north through
Hindsville. The route continues north, with US 412B terminating at a junction with
US 412 and Highway 45 terminating at
Highway 12 west of
Clifty. ==History==