Arnica montana

Arnica montana is a flowering plant about tall aromatic fragrant, herbaceous perennial. Its basal green ovate leaves with rounded tips are bright coloured and level to the ground. In addition, they are somewhat downy on their upper surface, veined and aggregated in rosettes. By contrast, the upper leaves are opposed, spear-shaped and smaller which is an exception within the Asteraceae. The chromosome number is 2n=38. The flowering season is between May and August (Central Europe). The flower heads are composed of orange-yellow disc florets in the centre which are externally bordered by 10 to 15 yellow ray florets. The achenes have a one-piece rough pappus which opens in dry conditions. Arnica montana is a hemicryptophyte, which helps the plant to survive the extreme overwintering condition of its habitat. In addition, Arnica forms rhizomes, which grow in a two-year cycle: the rosette part grows at its front while its tail is slowly dying. ==Taxonomy==

Arnica montana was given its scientific name in 1753 by Carl Linnaeus. It is part of the genus Arnica which is classified in the family Asteraceae. The Latin specific epithet montana refers to mountains or coming from mountains. It has two accepted subspecies. • '''Arnica montana subsp. atlantica'''Native to Portugal, Spain, and France. • '''Arnica montana subsp. montana'''The more widespread subspecies, found in all parts of its range except for Portugal. Arnica montana has synonyms of the species or one of its subspecies. ==Distribution and habitat==

Arnica montana is widespread across most of Europe. It is absent from the Celtic Isles and the Italian and Balkan peninsulas. In addition, it is considered extinct in Hungary and Lithuania. Nevertheless, it is cultivated on a large scale in Estonia. ==Chemical constituents==

The main constituents of Arnica montana are essential oils, fatty acids, thymol, pseudoguaianolide sesquiterpene lactones and flavanone glycosides. Pseudoguaianolide sesquiterpenes constitute 0.2–0.8% of the flower head of Arnica montana. They are the toxin helenalin and their fatty esters. 2,5-Dimethoxy-p-cymene and thymol methyl ether are the primary components of essential oils from both the plant's roots and rhizomes. The quality and chemical constitution of the plant substance Arnicae flos can be monitored by near-infrared spectroscopy. ==Cultivation==

Arnica montana is propagated from seed. Generally, 20% of seeds do not germinate. For large scale planting, it is recommended to raise plants first in a nursery and then to transplant them in the field. Seeds sprout in 14–20 days but germination rate depends highly on the seed quality. Planting density for Arnica montana is of 20 plants/m2 such that the maximum yield density will be achieved in the second flowering season. While Arnica montana has high exigencies of soil quality, analyses should be done before any fertilizer input. The flowers are harvested when fully developed and dried without their bract nor receptacles. The roots can be harvested in autumn and dried as well after being carefully washed. Arnica montana is sometimes grown in herb gardens. ==Use in herbal medicine==

Arnica montana has been used as a herbal medicine. When used as a topical medication in a gel at 50% concentration, A. montana was found to have the same effectiveness (albeit with possibly worse side effects) as a 5% ibuprofen gel for treating the symptoms of hand osteoarthritis. A 2014 review found that A. montana was ineffective at concentrations of 10% or less for pain, swelling, and bruises. A 1998 review of homeopathic A. montana (all such preparations are so dilute that they contain none of the plant) found it is no more effective than a placebo. Although a 2021 study found the drug to be more effective than placebo at preventing excessive hematoma comparable to that of anti-inflammatory substances. Contact with the plant can also cause skin irritation. In the Ames test, an extract of A. montana was found to be mutagenic. ==Market==

The demand for A. montana is 50 tonnes per year in Europe, but the supply does not cover the demand. The plant is rare; it is protected in Belgium, France, Germany, Italy, Poland, and in some regions of Switzerland. France and Romania produce A. montana for the international market. Changes in agriculture in Europe during the last decades have led to a decline in the occurrence of A. montana. Extensive agriculture has been replaced by intensive management. ==References==