Dempster joined the
physics faculty at the University of Chicago in 1916 and remained there until his death in 1950. He co-developed a double-focusing mass spectrograph in 1936 with the help of the Americans Kenneth T. Bainbridge and J.H.E. Mattauch of Austria. This apparatus allowed the measurement of the mass of atomic nuclei. During
World War II he worked on the secret
Manhattan Project to develop the world's first
atomic bomb. Dempster used a mass spectrometer of his design, in 1935 to find uranium-235, an isotope of uranium which is lighter than uranium-238. The quantity of uranium-235 in naturally occurring uranium is only 0.7%. Dempster was elected to the
American Philosophical Society in 1932 and the United States
National Academy of Sciences in 1937. From 1943 to 1946, Dempster was chief physicist of the University of Chicago's
Metallurgical Laboratory or "Met Lab" which integrally related to the Manhattan Project and was founded to study the materials necessary for the manufacture of atomic bombs. In 1946, he took a position as a division director at the
Argonne National Laboratory. Dempster died on March 11, 1950, in
Stuart, Florida, at the age of 63 of a myocardial infarction whilst on vacation. ==Research==