In 2016, Palmisciano made his television debut in an episode of the
BBC Two sitcom
Boy Meets Girl. He then began working with the charity Diversity Role Models, with whom he visited schools across the UK to talk about his experiences as a trans man. He described the work as the most terrifying thing he had done, but wished that he had heard the same talk as a child. In 2018, he wrote and directed a short film,
The Lady That Dances, which was broadcast on
Channel 4. He then worked for the
Royal Shakespeare Company and was the first trans actor to appear on their stage. After he informed producers that he was an actor, he was asked to audition for the part of
Matty Barton. The character, who was previously on the soap as Hannah (
Grace Cassidy), was reintroduced as a trans man that had transitioned off-screen. Palmisciano was originally contracted on
Emmerdale for a three-month-long stint, but it was soon renewed and he has remained on the soap since. At the
2018 Inside Soap Awards, he won the accolade for Best Newcomer. In 2023, he became a judge on the
National Diversity Awards panel. ==Personal life==