Atherosperminine, or atherospermine, is a dopamine receptor agonist, alkaloid found in Fissistigma glaucescens and other species, and the Hofmann degradation product of the aporphine alkaloid and dopamine receptor antagonist nuciferine. It is a catecholamine with an expanded phenanthrene ring system and contains the neurotransmitter dopamine within its chemical structure. The drug produces effects in rodents including hyperlocomotion, stereotypy, augmentation of amphetamine-induced toxicity, and reversal of haloperidol-induced catalepsy, among others. Its effects are largely opposite to those of nuciferine, which instead shows antipsychotic-like effects. In addition to its dopamine receptor agonism, atherosperminine has also shown other actions and effects, such as phosphodiesterase inhibition.