In 2012, Markopoulou was appointed to the faculty at the
University of California, Irvine. Her research group, the UCI Networking Group, considers mobile data analytics, privacy and the
internet of things. Markopoulou has looked to understand advertising and tracking services, and train
machine learning models for the detection and blocking of advertising. She co-founded
Shoelace Wireless, an app that speeds up mobile internet by combining
Wi-Fi and
cellular networks. In 2020, Markopoulou was awarded $10 million from the
National Science Foundation to study personal information, data and security. The program, ProperData: Protecting Personal Data Flow on the Internet, seeks to protect personal data on mobile devices. She was the first
Samueli School of Engineering researcher to be appointed Chancellor's Fellow at the
University of California, Irvine in 2019. == Awards and honors ==