A businessman, Blackmer, visits the reclusive Dr Orchard, a scientist who lives in a dilapidated house on the Ambro River. From the local plant
Sidonicus americanus, Orchard has developed a
food additive called "theramine" that
increases the size of animals. Enlargement of animal stock presents a simple solution to world
famine as well as other economic advantages. Blackmer's boatman, Culp, has been eavesdropping on the meeting. When a storm forces Blackmer to stay at the house overnight, Culp decides to steal the theramine and sell it to the highest bidder. Waiting until the house's other occupants are asleep, he breaks into Orchard's laboratory and pours some theramine into a vial; in the process, he accidentally tips some of the drug into a sink, washing it away into the Ambro River. When Blackmer and Culp leave the next morning, their boat is attacked by an alligator, now enormous due to the theramine contamination. Orchard's assistant, Hector McGill, manages to rescue Blackmer but Culp is seemingly lost. The house is quickly surrounded by three giant alligators that repeatedly hurl themselves at the building with Orchard, Blackmer, McGill and the housekeeper, Mrs Files, trapped inside. At Mrs Files' suggestion, McGill transmits a distress call to International Rescue. This is picked up by
John Tracy on the
Thunderbird 5 space station and relayed to
Tracy Island, where
Jeff immediately dispatches his other four sons to the danger zone in
Thunderbirds 1 and
2. Arriving in
Thunderbird 1 and transferring to a hover-jet,
Scott fires the hover-jet's missile gun to disperse the alligators and accesses the house via the laboratory window. The room eventually caves in, forcing Scott and the others to retreat to the lounge. There, they are confronted by Culp, who holds them at gunpoint.
Virgil,
Alan and
Gordon arrive in
Thunderbird 2. Alan and Gordon man
tranquiliser guns and subdue two of the alligators. When the third returns to the house, Alan exits
Thunderbird 2 on another hover-jet to lure it away. He crashes and is knocked unconscious-jet but is saved by Gordon, who tranquilises the alligator before it reaches Alan. Threatening to empty the entire theramine vial into the Ambro unless he is given safe passage upriver, Culp sets off in Blackmer's boat. At the same time, Gordon launches
Thunderbird 4. A fourth, large alligator appears and attacks the boat, killing Culp. Virgil disposes of the creature with a missile fired from
Thunderbird 2. Gordon manages to recover the theramine vial intact on the riverbed. Back on Tracy Island, Jeff reveals that Blackmer and Orchard have announced that theramine will be subject to international security restrictions.
Tin-Tin, who has been away on a shopping trip and missed the rescue, has bought Alan a present for his birthday – a
pygmy alligator. ==Regular voice cast==