Akinloye was instrumental to the formation of the first ever political party in Ibadan called
Ibadan Peoples Party (IPP) which he served as its president, with
Adegoke Adelabu as his deputy. His IPP party later merged with the
Action Group, led by Chief
Obafemi Awolowo, to form the first government in the
Western Region of Nigeria, in which Akinloye was appointed the Minister of Agriculture and Natural Resources. During the second half of the 1950s he was elected Chairman of Ibadan City Council. During the Western Region crisis in the early 1960s, he left the Action Group for Chief
Samuel Ladoke Akintola's newly formed
Nigerian National Democratic Party and served in the cabinet led by the then Prime Minister,
Abubakar Tafawa Balewa. (The government was overthrown in a military coup on 15 January 1966.) ==Second Republic==