Pre-draft Seferian-Jenkins was a projected a second-round selection by
CBS Sports in the 2014 NFL draft. {{NFL predraft
Tampa Bay Buccaneers 2014 season Seferian-Jenkins was selected by the
Tampa Bay Buccaneers in the second round with the 38th overall pick in the 2014 NFL draft. In his rookie season, Sefarian-Jenkins played in nine games making 21 catches for 221 yards and two touchdowns. On October 26, he caught his first career touchdown, which was a seven-yard pass from
Mike Glennon, against the
Minnesota Vikings. He caught his second and last touchdown of the season, a one-yard pass from
Josh McCown, against the
Atlanta Falcons. His season was cut short by an injury, landing him on the team's
injured reserve list.
2015 season In the 2015 season, with rookie quarterback and first overall pick
Jameis Winston, Seferian-Jenkins looked to expand on his rookie season. He had a career day in a season opening loss to the
Tennessee Titans. He had five receptions for 110 yards and two touchdowns, which were a five-yard reception in the second quarter and a 41-yard reception in the fourth quarter. Both of Seferian-Jenkins's touchdowns were the first touchdown passes of Winston's NFL career. Seferian-Jenkins's remainder of his 2015 season would not have the success he had in the season opener. He only scored two more touchdowns on the season, which were a nine-yard reception from Winston against the
St. Louis Rams and a 43-yard reception from Winston against the
Chicago Bears. He played in seven games with 338 receiving yards and four touchdowns.
2016 season Seferian-Jenkins played in the season opener against the Falcons at the
Georgia Dome. He had one reception for 30 yards and a touchdown, which would be his only one of the 2016 season. He played one more game with the Buccaneers on September 18, which was against the
Arizona Cardinals at the
University of Phoenix Stadium. He had two receptions for 14 yards in the 40–7 loss. On September 23, 2016, Seferian-Jenkins was arrested on a DUI charge and was released by the Buccaneers later that day.
New York Jets 2016 season On September 26, 2016, Seferian-Jenkins was claimed off waivers by the
New York Jets. Seferian-Jenkins recorded 10 total receptions for 110 yards in seven games with the Jets.
2017 season On March 15, 2017, Seferian-Jenkins was suspended the first two weeks of the 2017 season for violating the NFL Policy and Program for Substances of Abuse. During Week 6 against the
New England Patriots, Seferian-Jenkins was thought to have fumbled inches from the
endzone, resulting in a touchback. The call was controversial, since he retained possession going to the ground and only momentarily appeared to shift the ball as he crossed the
goal line, but ultimately the error loomed large, as the Jets lost the game 17–24. He played in 13 games, of which he started ten, in the 2017 season. He finished with 50 receptions for 357 receiving yards and three receiving touchdowns.
Jacksonville Jaguars On March 15, 2018, Seferian-Jenkins signed a two-year, $10 million contract with the
Jacksonville Jaguars. He was placed on injured reserve on October 9, 2018, after aggravating a core muscle injury. He played in five games in the 2018 season. He recorded 11 receptions for 90 receiving yards and one touchdown. On February 18, 2019, the Jaguars declined the option on Seferian-Jenkins' contract, making him a free agent at the start of the new league year.
New England Patriots On April 10, 2019, Seferian-Jenkins signed a one-year contract with the
New England Patriots. He was released on June 4, 2019, citing personal issues. ==Career statistics==