Autonomic nervous system

s in middle, and the vagus nerve as "X" in blue. The heart and organs below in list to right are regarded as viscera. The autonomic nervous system has been classically divided into the sympathetic, parasympathetic and enteric nervous systems. More modern classifications recognize other networks that integral to different organs, such as the intrinsic cardiac nervous system. The sympathetic division emerges from the spinal cord in the thoracic and lumbar areas, terminating around L2-3. The parasympathetic division has craniosacral "outflow", meaning that the neurons begin at the cranial nerves (specifically the oculomotor nerve, facial nerve, glossopharyngeal nerve and vagus nerve) and sacral (S2-S4) spinal cord. These divisions are distinctive because they require a sequential two-neuron efferent pathway; the preganglionic neuron must first synapse onto a postganglionic neuron before innervating the target organ. The preganglionic, or first, neuron will have its nerve cell body in the central nervous system and will synapse at the postganglionic, or second, neuron's cell body. The postganglionic neuron will then form junctions within the target organ. Sympathetic division The sympathetic nervous system consists of cells with bodies in the lateral grey column from T1 to L2/3. These cell bodies are "GVE" (general visceral efferent) neurons and are the preganglionic neurons. There are several locations upon which preganglionic neurons can synapse for their postganglionic neurons: • paravertebral ganglia (3) of the sympathetic chain (these run on either side of the vertebral bodies) • cervical ganglia (3) • thoracic ganglia (12) and rostral lumbar ganglia (2 or 3) • caudal lumbar ganglia and sacral ganglia • prevertebral ganglia (celiac ganglion, aorticorenal ganglion, superior mesenteric ganglion, inferior mesenteric ganglion) • chromaffin cells of the adrenal medulla (this is the one exception to the two-neuron pathway rule: the synapse is directly efferent onto the target cell bodies) These ganglia provide the postganglionic neurons from which innervation of target organs follows. Examples of splanchnic (visceral) nerves are: • cervical cardiac nerves and thoracic visceral nerves, which synapse in the sympathetic chain • thoracic splanchnic nerves (greater, lesser, least), which synapse in the prevertebral ganglia • lumbar splanchnic nerves, which synapse in the prevertebral ganglia • sacral splanchnic nerves, which synapse in the inferior hypogastric plexus These all contain afferent (sensory) nerves as well, known as GVA (general visceral afferent) neurons. Parasympathetic division The parasympathetic nervous system consists of cells with bodies in one of two locations: the brainstem (cranial nerves III, VII, IX, X) or the sacral spinal cord (S2, S3, S4). These are the preganglionic neurons, which synapse with postganglionic neurons in these locations: • parasympathetic ganglia of the head: ciliary (cranial nerve III), geniculate (cranial nerve VII), • pterygopalatine (cranial nerve VII and IX), and submandibular (cranial nerve VII and IX), • ottic in inner ear space (cranial nerve IX) • tympanic nerve of VII with C9, C10, C5 (cranial nerves VII, XI, X, V) in promontory plexus in middle ear space • trigeminal ganglion specially sensory (only mastication motor) is common with other ones • in or near the wall of an organ innervated by the vagus (cranial nerve X) or sacral nerves plexus (S2, S3, S4) These ganglia provide the postganglionic neurons from which innervations of target organs follows. Examples are: • the postganglionic parasympathetic splanchnic (visceral) nerves • the vagus nerve, which passes through the thorax and abdominal regions innervating, among other organs, the heart, lungs, liver and stomach Enteric nervous system Development of the enteric nervous system Development of the enteric nervous system involves migration of cells from the vagal section of the neural crest, eventually populating the entire gastrointestinal tract. Having about 200 million neurons, the ENS communicates with the central nervous system while regulating gut function independently. Motor neurons Motor neurons of the autonomic nervous system are found in "autonomic ganglia". Those of the parasympathetic branch are located close to the target organ whilst the ganglia of the sympathetic branch are located close to the spinal cord. The sympathetic ganglia here, are found in two chains: the pre-vertebral and pre-aortic chains. The activity of autonomic ganglionic neurons is modulated by "preganglionic neurons" located in the central nervous system. Preganglionic sympathetic neurons are located in the spinal cord, at the thorax and upper lumbar levels. Preganglionic parasympathetic neurons are found in the medulla oblongata where they form visceral motor nuclei; the dorsal motor nucleus of the vagus nerve; the nucleus ambiguus, the salivatory nuclei, and in the sacral region of the spinal cord. ==Function==

Sympathetic and parasympathetic divisions typically function in opposition to each other. But this opposition is better termed complementary in nature rather than antagonistic. For an analogy, one may think of the sympathetic division as the accelerator and the parasympathetic division as the brake. The sympathetic division typically functions in actions requiring quick responses. The parasympathetic division functions with actions that do not require immediate reaction. The sympathetic system is often considered the "fight or flight" system, while the parasympathetic system is often considered the "rest and digest" or "feed and breed" system. However, many instances of sympathetic and parasympathetic activity cannot be ascribed to "fight" or "rest" situations. For example, standing up from a reclining or sitting position would entail an unsustainable drop in blood pressure if not for a compensatory increase in the arterial sympathetic tonus. Another example is the constant, second-to-second, modulation of heart rate by sympathetic and parasympathetic influences, as a function of the respiratory cycles. In general, these two systems should be seen as permanently modulating vital functions, in a usually antagonistic fashion, to achieve homeostasis. Higher organisms maintain their integrity via homeostasis which relies on negative feedback regulation which, in turn, typically depends on the autonomic nervous system. Some typical actions of the sympathetic and parasympathetic nervous systems are listed below. Sympathetic nervous system Promotes a fight-or-flight response, corresponds with arousal and energy generation, and inhibits digestion • Diverts blood flow away from the gastro-intestinal (GI) tract and skin via vasoconstriction • Blood flow to skeletal muscles and the lungs is enhanced (by as much as 1200% in the case of skeletal muscles) • Dilates bronchioles of the lung through circulating epinephrine, which allows for greater alveolar oxygen exchange • Increases heart rate and the contractility of cardiac cells (myocytes), thereby providing a mechanism for enhanced blood flow to skeletal muscles • Dilates pupils and relaxes the ciliary muscle to the lens, allowing more light to enter the eye and enhances far vision • Provides vasodilation for the coronary vessels of the heart • Constricts all the intestinal sphincters and the urinary sphincter • Inhibits peristalsis • Stimulates orgasm The pattern of innervation of the sweat gland—namely, the postganglionic sympathetic nerve fibers—allows clinicians and researchers to use sudomotor function testing to assess dysfunction of the autonomic nervous systems, through electrochemical skin conductance. Parasympathetic nervous system The parasympathetic nervous system has been said to promote a "rest and digest" response, promotes calming of the nerves return to regular function, and enhancing digestion. Functions of nerves within the parasympathetic nervous system include: • Dilating blood vessels leading to the GI tract, increasing the blood flow. • Constricting the bronchiolar diameter when the need for oxygen has diminished • Dedicated cardiac branches of the vagus and thoracic spinal accessory nerves impart parasympathetic control of the heart (myocardium) • Constriction of the pupil and contraction of the ciliary muscles, facilitating accommodation and allowing for closer vision • Stimulating salivary gland secretion, and accelerates peristalsis, mediating digestion of food and, indirectly, the absorption of nutrients • Sexual. Nerves of the peripheral nervous system are involved in the erection of genital tissues via the pelvic splanchnic nerves 2–4. They are also responsible for stimulating sexual arousal. Enteric nervous system The enteric nervous system is the intrinsic nervous system of the gastrointestinal system. It has been described as the "second brain of the human body". Its functions include: • Sensing chemical and mechanical changes in the gut • Regulating secretions in the gut • Controlling peristalsis and some other movements Neurotransmitters At the effector organs, sympathetic ganglionic neurons release noradrenaline (norepinephrine), along with other cotransmitters such as ATP, to act on adrenergic receptors, with the exception of the sweat glands and the adrenal medulla: • Acetylcholine is the preganglionic neurotransmitter for both divisions of the ANS, as well as the postganglionic neurotransmitter of parasympathetic neurons. Nerves that release acetylcholine are said to be cholinergic. In the parasympathetic system, ganglionic neurons use acetylcholine as a neurotransmitter to stimulate muscarinic receptors. • At the adrenal medulla, there is no postsynaptic neuron. Instead, the presynaptic neuron releases acetylcholine to act on nicotinic receptors. Stimulation of the adrenal medulla releases adrenaline (epinephrine) into the bloodstream, which acts on adrenoceptors, thereby indirectly mediating or mimicking sympathetic activity. A full table is at Table of neurotransmitter actions in the ANS. Autonomic nervous system and the immune system Recent studies indicate that ANS activation is critical for regulating the local and systemic immune-inflammatory responses and may influence acute stroke outcomes. Therapeutic approaches modulating the activation of the ANS or the immune-inflammatory response could promote neurologic recovery after stroke. == History ==

In 1665, Thomas Willis used the terminology, and in 1900, John Newport Langley used the term, defining the two divisions as the sympathetic and parasympathetic nervous systems. ==Caffeine effects==

Caffeine is a bioactive ingredient found in commonly consumed beverages such as coffee, tea, and sodas. Short-term physiological effects of caffeine include increased blood pressure and sympathetic nerve outflow. Habitual consumption of caffeine may inhibit physiological short-term effects. Consumption of caffeinated espresso increases parasympathetic activity in habitual caffeine consumers; however, decaffeinated espresso inhibits parasympathetic activity in habitual caffeine consumers. It is possible that other bioactive ingredients in decaffeinated espresso may also contribute to the inhibition of parasympathetic activity in habitual caffeine consumers. Caffeine is capable of increasing work capacity while individuals perform strenuous tasks. In one study, caffeine provoked a greater maximum heart rate while a strenuous task was being performed compared to a placebo. This tendency is likely due to caffeine's ability to increase sympathetic nerve outflow. Furthermore, this study found that recovery after intense exercise was slower when caffeine was consumed prior to exercise. This finding is indicative of caffeine's tendency to inhibit parasympathetic activity in non-habitual consumers. The caffeine-stimulated increase in nerve activity is likely to evoke other physiological effects as the body attempts to maintain homeostasis. The effects of caffeine on parasympathetic activity may vary depending on the position of the individual when autonomic responses are measured. One study found that the seated position inhibited autonomic activity after caffeine consumption (75 mg); however, parasympathetic activity increased in the supine position. This finding may explain why some habitual caffeine consumers (75 mg or less) do not experience short-term effects of caffeine if their routine requires many hours in a seated position. The data supporting increased parasympathetic activity in the supine position was derived from an experiment involving participants between the ages of 25 and 30 who were considered healthy and sedentary. Caffeine may influence autonomic activity differently for individuals who are more active or elderly. == See also ==