Luke Spencer (
Anthony Geary) tracks down art dealer Ava Jerome at her home in
New York City. Luke gets Ava to confess that she was once involved with the crazed artist
Robert "Franco" Frank (
Roger Howarth) and that he fathered her daughter,
Lauren Katherine "Kiki" Jerome (
Kristen Alderson). Ava is shocked to learn from Luke that Franco is an heir to the wealthy and powerful
Quartermaine family and that Lauren is entitled to a share of the family fortune. After Luke's visit, it is revealed that
Morgan Corinthos (Bryan Craig), the missing son of mob boss,
Sonny Corinthos (
Maurice Benard) is hiding out in Ava's apartment. Before leaving for work, Ava convinces Morgan to call home. Ava follows her daughter to
Port Charles and has an impromptu meeting with
Tracy Quartermaine (
Jane Elliot) over Kiki's shares, and manages to work out a deal that would endow her with a large money sum. Ava then confronts her daughter about the latest revelations and confesses that her father is in fact alive, leaving Kiki in a state of anger against her mother. Whilst in town, Ava runs
Dr. Silas Clay (
Michael Easton), with whom she previously had a fling. When Silas begins to question whether or not Kiki is his, Morgan confronts Ava about the truth to which she reveals that Kiki is not Franco's, but in fact is Silas' daughter. When Ava's older brother, the presumed dead
Julian Jerome (
William deVry) arrives in town under the alias "Derek Wells", the two reveal how their gambling ring involvement with Morgan was all in a hoax to work their way into the
Corinthos family crime organization. Ava also confesses to Julian her involvement in the shooting of
Olivia Falconeri (
Lisa LoCicero). While on a discovery to find out about her birth father,
Sam Morgan (
Kelly Monaco) and Silas travel to
New York and discover that
Delia Ryan (
Ilene Kristen), who had an affair with Victor, was Ava's birth mother. During a heated confrontation,
A. J. Quartermaine (
Sean Kanan) confronts Ava about the night that
Connie Falconeri (
Kelly Sullivan) was murdered; Ava then confesses it was she who murdered Connie, not A. J., due to Connie discovering the truth about "Derek" and Ava's connection. Sonny interrupts and shoots A. J., killing him as a result. During A. J.'s funeral, Ava sleeps with Sonny in the Quartermaine family crypt, and is discovered by Morgan, who breaks their relationship off. To escape town, Sonny sends Ava to his private island to hide out, after Carly finds out the truth about A. J.'s death. While on the island, Sonny confronts Ava, and confesses he knows the truth about Ava's involvement in the shootings of both Olivia and Connie, and promises to kill her. Ava then confesses that she is pregnant, with either Sonny or Morgan's child, guaranteeing her nine more months of life from Sonny. Following a kidnapping from Nina, Ava gives birth to her daughter, whom Nina abducts and intends to raise as her own. When her daughter is found in Canada, they are briefly reunited when Ava is placed under arrest for Connie's murder. Teaming up with Madeline, Julian and Sonny, she breaks out of prison, only to be shot in the chest by Carlos and believed to be dead when her body is not found after falling into a river. In New York, Silas keeps Ava, whom he rescued and unveils that she is battling cancer. When the cancer spreads at quicker than Silas imagined, Ava requests to be euthanized, choosing to end her life on her own terms. One month after her loved ones believe her to be dead, a
doppelgänger by the name of Denise DeMuccio arrives and claims to be inquiring about Ava's family, considering their resemblance. When Denise is arrested and fingerprinted, she is questioned and accused of truly being Ava in disguise, however, when the DNA test performed by Ava's nephew
Lucas Jones (
Ryan Carnes) comes back proving that Ava and Denise are two different people, she is released from custody. When confronted by Silas, Denise confesses to being Ava and that she teamed up with her mother to pull off the switch in an attempt to be in the lives of her daughters without the threat of the PCPD or Sonny. In June 2016, while on a plane to
England, Ava stumbles upon
Nikolas Cassadine (Christopher), who is believed to be dead. While traveling, Ava and Nikolas (under the alias of "Niall Carradine"), run into Huxley Lynch (
Trent Dawson), who ultimately entraps them within his home. Believing that Huxley wants Nik (
Nick Stabile), they confront him and demand for their release; Huxley admits it is Ava he is truly after, due to her ownership of the "Weeping Naiad". Upon their escape, Nik and Ava make their way to
Greece and end up on Cassadine Island, where they are discovered by Jason and Sam Morgan. When confronted to go back to Port Charles and joined by several of Nikolas' family members, Ava and the other guests on Cassadine Island are taken hostage by
Valentin Cassadine (
James Patrick Stuart). Ava is then held at gun point by Valentin, and in an attempt to save Ava's life, Nikolas is ultimately shot and falls out of a window. == Reception ==