Santamaria is a youth exponent from
Tours. He made his
Ligue 2 debut on 18 October 2013 against
CA Bastia replacing
Bryan Bergougnoux after 88 minutes in a 2–1 away win at the
Stade Armand Cesari. On 25 June 2016, Santamaria joined
Ligue 1 side
Angers after a transfer fee offer of €400,000 from Angers to Tours had previously been rejected by the latter. In September 2020, Santamaria moved to
Bundesliga club
SC Freiburg after protracted negotiations with Angers. German sports magazine
kicker reported the transfer fee as "about €10 million", the highest in SC Freiburg's history. On 22 January 2025, Santamaria was loaned to
Nice for the remainder of the 2024–25 season, with an option to buy. On 7 August 2025, Santamaria moved to La Liga club
Valencia on a 2-year deal. ==Career statistics==