Aloin

Aloin extracted from natural sources is a mixture of two diastereomers, termed aloin A (also called barbaloin) and aloin B (or isobarbaloin), which have similar chemical properties. Aloin is an anthraquinone glycosyl, meaning that its anthraquinone skeleton has been modified by the addition of a sugar molecule. Anthraquinones are a common family of naturally occurring yellow, orange, and red pigments of which many have cathartic properties, attributes shared by aloin. Aloin is related to aloe emodin, which lacks a sugar group but shares aloin's biological properties. Aloin is usually prepared by extraction from aloe latex (the term "Cape aloe" also refers to the dried latex of the leaves of several species of the genus Aloe, especially A. ferox [Blumenthal, 1998]), the bitter yellow exudate that seeps out from just underneath the skin of aloe leaves. The latex is then dried and powdered to make the final product, often made into tablets or a beverage, though aloin does not have good stability in aqueous solutions. Products derived from the gel of the aloe plant do not contain appreciable amounts of aloin, and have not been proven effective for any disease or condition when taken orally. ==Effects==

Once ingested, aloin increases peristaltic contractions in the colon, which induces bowel movements. Aloin also prevents the colon from re-absorbing water from the gastrointestinal tract, which leads to softer stools. In a study on consumption of aloe in rats and tilapia (with no separation of gel from aloin), significant negative health effects were found, including normocytic normochromic anaemia (low red blood cell count, but normal cells), hypoproteinaemia, and high AST levels. As many studies involving aloe gel (without aloin) have not observed these negative effects, it is possible that the negative effects could in large part be due to aloin. == Legal status ==

Plant-derived remedies containing aloin and other anthraquinones have been used as traditional medicines since antiquity, but harsh side effects make these substances generally unsuitable for household or daily use. In 2002, the US FDA mandated that manufacturers reformulate or stop manufacturing over-the-counter products containing aloe because the agency did not receive necessary safety data. The substance is still allowed in dietary supplements [21 U.S.C. 321 (ff)(1)] and is allowed for use in foods (primarily alcoholic beverages). == References ==