Barbara was born in Dresden in 1405 as the eldest daughter of
Rudolf III, Duke of Saxe-Wittenberg and his second wife, Barbara of Silesia-Liegnitz. She had three brothers, Rudolf (died 1406), Wenceslas (died 1407), and Sigismund (died 1407), and a half-sister, Scholastica (1393–1463; married to
Jan I of Żagań), from her father's first marriage to Anne of Meissen. Sigismund and Wenceslas were killed in the collapse of a castle tower. Barbara was betrothed at an early age to John of Brandenburg-Kulmbach, who was one year younger than she. She married John in 1416 when she was eleven and he ten. The marriage was arranged by the future Emperor Sigismund, who had initially planned to grant John the
Electorate of Saxony, though this plan was abandoned. The couple resided for a long time at
Plassenburg castle near Kulmbach, then later at
Scharfeneck Palace near Baiersdorf, and finally in a city apartment in Nuremberg. Barbara spent the time after her husband's death in Bayreuth. She died there on October 10, 1465, almost a year after her husband's death. ==Family and children==