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Bridgehampton School, nickname of a high school basketball team featured in the 2017 documentary film •
The Killer Bees (professional wrestling), a professional wrestling tag team •
Killer B's (Houston Astros), collective nickname for six Houston Astros players in the 1990s and early 2000s •
Killer B's (Miami), collective nickname for eight Miami Dolphins defensive players in the 1980s •
Rio Grande Valley Killer Bees (disambiguation) •
Rio Grande Valley Killer Bees (NAHL), a former North American Hockey League team based in Hidalgo, Texas, US •
Rio Grande Valley Killer Bees (CHL), a former Central Hockey League team based in Hidalgo, Texas, US •
Group B, a 1980s class of World Rally Championship cars nicknamed "Killer B's" due to their poor safety record •
Killer B's (Pittsburgh), a nickname for three players for the 2013–2017 Pittsburgh Steelers: Ben Roethlisberger, Antonio Brown, and Le'Veon Bell ==Video games==