He was created cardinal priest in the
consistory of 3 May 1527 with the title of
Sant'Eusebio, again after his uncle. On 17 August 1524, he was promoted to the metropolitan see of
Ravenna after his uncle. He was named administrator of
Diocese of Bovino and then of the
Diocese of Policastro until 1535. In addition,
James V of Scotland appointed him Cardinal-Protector of Scottish Affairs at Rome, dealing with church appointments and negotiations for the King's marriage. His uncle, the Cardinal of Ancona, had performed this role since the regency of the
Duke of Albany. He participated in the
Conclave in 1534. The new
Pope Paul III deprived him of his cardinalate on 27 August 1534, and imprisoned him in the
Castel Sant'Angelo, accusing him of misspending 19,000 ducats for the expedition against the Turks. The next year he paid a large sum of money and was restored to the cardinalate under some conditions. He wrote some works in Latin, including poetry. At the request of the later Pope, he wrote a treatise to assert the right of the pope to the
Kingdom of Naples.He died in Florence on 21 September 1549 in Florence and was buried in the church of S. Lorenzo, Florence. ==References==