From the beginning of his career Bengt Mannervik studied enzymes of glutathione metabolism, including studies of levels in different tissues, structure and catalytic activity of glutathione transferase, a purification method, a detailed review on the isoenzymes of
glutathione transferase, In all he has had nearly 600 publications, with a combined total of more than 47000 citations. His interest in glutathione transferases continued until the last years of his research, for example studies of their role as efficient ketosteroid isomerases and as enzymes involved in the biosynthesis of
moulting hormones in
mosquitoes transmitting
malaria and
yellow fever. In addition to the work directed specifically at enzymes involved in glutathione metabolism and
detoxication, Mannervik coauthored texts on molecular
toxicology.
error structure of kinetic experiments,
regression methods,
directed enzyme evolution, and
discrimination between models. Major contributions were more recently directed to the evolution of novel functions by
in vitro protein evolution.
Doctoral supervision Mannervik has supervised more than 60 PhD students and among them
Tamas Bartfai, U. Helena Danielson, Mikael Widersten, Per Jemth, Ylva Ivarsson, Vijayakumar Boggaram, M. Kalim Tahir, Usama Hegazy, and Abeer Shokeer have become university professors. == Honours ==