Hall's graduate thesis research identified the two major RNAs (18S and 28S) of the eukaryotic
ribosome, After accepting a faculty appointment at the
University of Illinois in 1958, Hall conducted studies of the RNA generated by
T4 phage when infecting
E. coli. By developing molecular
hybridization techniques, his lab demonstrated that such RNAs had complementary sequences to those of the bacteriophage DNA, In 1963 Hall joined the faculty of the Department of Genetics at the University of Washington. Hall's subsequent accomplishments included the first demonstration of linkage between a DNA polymorphism and a phenotype, the discovery of
tRNA introns, and production of the first DNA sequence of a
mutant eukaryotic gene. Hall's group also conducted studies of transcription by
S. cerevisiae RNA Polymerases, Based on these findings, Hall and colleagues developed methods for the expression of genetically engineered proteins in yeast. Later in his career Hall studied the molecular systematics, taxonomy, and evolutionary history of fungi and flowering plants, In collaboration with
Jay Shendure’s laboratory, Hall's group determined the genome sequence of the
Rhododendron species
R. williamsianum. The Benjamin D. Hall Interdisciplinary Research Building at the University of Washington was dedicated in Hall's honor in 2006. == Honors ==