Shapiro worked in private practice in New York, and also was a lawyer for the
United States Department of Transportation in the 1960s. In 1979, he became an attorney for the Illinois-based G. D. Searle. Shapiro was a co-founder of
Sandbox Industries, a Chicago-based business incubator and venture fund manager in 2003, and served as one of its managing directors. He was on the board of
Conservis, a Sandbox funded firm. Shapiro was an early member of the board of directors of
Theranos, the company created by
Elizabeth Holmes. ==Personal life and death==