Giese specializes in the bio-
organic chemistry and synthesis of radicals in biological systems. He contributed to the understanding of radical induced
DNA cleavage and of the DNA synthesis by
ribonucleotide reductase. The formation of carbon–carbon bonds by addition of free radicals to
alkenes is called the
Giese reaction. Giese developed concepts, guidelines, and synthetic applications for the stereochemistry of radical reactions. ==Awards==