Wiesberger played on the
Challenge Tour in 2007 and 2008. He earned his
European Tour card for the 2009 season through
qualifying school. He was unable to win enough money during his rookie season to retain his card and returned to the Challenge Tour. Wiesberger won two events, the
Allianz Golf Open de Lyon and the
Allianz Golf Open du Grand Toulouse, en route to a 5th-place finish on the Order of Merit, good enough for a European Tour card for 2011. Wiesberger recorded four top-10 finishes in his return to the European Tour in 2011 including two runner up finishes. He finished 64th on the Order of Merit. Wiesberger claimed his maiden title on the European Tour in 2012 at the
Ballantine's Championship, twice setting the course record and winning the championship by the margin of five strokes. The win moved him into the top 100 of the
Official World Golf Ranking. In July 2012, Wiesberger won his second title of the year and of his European Tour career at the
Lyoness Open, held in his home country of Austria. He started the final round four strokes back of
Thorbjørn Olesen, but a round of 65 seven under par, including birdies at three of the last four holes secured a three stroke victory. He became only the second Austrian to win his home Open, after
Markus Brier in 2006. After the victory he said: "It's the best day of my life so far. It seems like it went my way, especially the last two holes. I had such a great country and such great fans backing me. I'm very proud to be following in such big footsteps [as Brier]. I'm sure I'm not going to be the last home winner." On 5 May 2013, Wiesberger won his sixth professional tournament and the second of his career in Asia, beating reigning
Open Champion Ernie Els by a shot at the
CIMB Niaga Indonesian Masters for his first win of the season. In 2014, he lost a playoff at his home event, the
Austrian Open. However, he earned enough world ranking points to place 60th in the world and become the first Austrian to play in the
U.S. Open. Wiesberger had the last guaranteed position for entry and it was the event immediately after the Austrian Open. At the
2014 PGA Championship, Wiesberger was one off the lead of
Rory McIlroy after 54 holes at
Valhalla Golf Club and was paired with McIlroy in the final round of the championship. However, Wiesberger shot a three-over par round on the final day and finished in a tie for 15th. In May 2015, Wiesberger lost in a three-man sudden-death playoff at the
Dubai Duty Free Irish Open. He started the final round two strokes behind
Søren Kjeldsen and despite shooting a 74, entered the playoff with Kjeldsen and
Eddie Pepperell. Kjeldsen won on the first extra hole with a birdie. Wiesberger has lost all three sudden-death playoffs in his European Tour career. On 5 July Wiesberger would win his third event on the European Tour when he took the
Alstom Open de France. Wiesberger took victory by three strokes over Englishmen
James Morrison, Wiesberger had also started the round four strokes back of South African
Jaco van Zyl but stormed back with final round 66. With this being his third win on tour, he became the most successful Austrian golfer in the history of the European Tour, moving ahead of
Markus Brier, who had two wins;
Martin Wiegele was the only other Austrian with a win. Wiesberger claimed his fourth European Tour victory at the 2017
Shenzhen International. He won with a birdie at the first extra hole, in a sudden-death playoff, to defeat
Tommy Fleetwood. Fleetwood had earlier shot a final round of 63 to come from eight strokes back and set the clubhouse lead. Wiesberger had to scramble for pars on the back nine and then almost holed his approach shot on the 72nd hole for the victory. In the playoff, Wiesberger found trouble from the tee, but hit his approach to within five feet for birdie to claim victory. His fourth victory came in his 200th event on the European Tour. On 26 May 2019, Weisberger won his fifth European Tour title at the
Made in Denmark at Himmerland Golf & Spa Resort. He won by shooting a final-round 66. On 14 July 2019, he won the
Aberdeen Standard Investments Scottish Open at
Renaissance Club in
North Berwick,
Scotland. He won in a playoff over
Benjamin Hébert. On 13 October 2019, he won the
Italian Open for his third victory of the European Tour season. This pushed him to first place in the season long
Race to Dubai. In May 2021, Wiesberger successfully defended his title at the
Made in HimmerLand event. He shot a final-round 64 to win by five shots and advanced back to the top 50 in the
Official World Golf Ranking. Four weeks later he followed that with a tied-for-fifth-place finish at the
BMW International Open, to increase his chances of a selection to the 2021 European Ryder Cup team. In August, Wiesberger looked set to claim his ninth European Tour victory at the
Omega European Masters. He had a one shot lead going down the final hole, however a double-bogey saw him drop into second place; one shot behind
Rasmus Højgaard. In September 2021, Wiesberger played on the European team in the
2021 Ryder Cup at
Whistling Straits in
Kohler, Wisconsin, becoming the first Austrian Ryder Cup player ever. The U.S. team won 19–9 and Wiesberger went 0–3–0 including a loss in his Sunday singles match against
Brooks Koepka. In 2022, Wiesberger signed with
LIV Golf League. Prior to the start of 2024, he returned to the
DP World Tour. ==Amateur wins==