Berthold returned to Greece in 1207 or 1208. In the meantime, Boniface of Montferrat had been killed fighting against the
Bulgarians, and had left his underage son
Demetrius as his heir, with the latter's mother,
Margaret of Hungary, as regent and Count
Oberto II of Biandrate as guardian (
baiulus) of the kingdom. In 1208–09, the kingdom's barons, rejecting the suzerainty of the emperor, now Henry of Flanders, rose against the regent in the so-called "Lombard Rebellion". Led by Oberto, the rebels intended to depose Demetrius and install his elder half-brother,
William VI of Montferrat, as king. During the uprising, Berthold loyally supported the emperor and was named as
castellan of
Serres. After the emperor arrested Oberto, he handed him over to Berthold, who held him imprisoned in Serres. Berthold supported Boniface's policy of maintaining good relations with the Byzantine aristocracy, as against the preferred policy of the rebels, which was to favour Lombards in the government. Berthold even patronised the family of
Petraliphas, giving the monastery of Saint Hilarion near
Halmyros to
Maria Petraliphaina. In 1209, Berthold attended the
first Parliament of Ravennika. It appears that around this time the Emperor Henry appointed him imperial guardian or regent of the kingdom,
balivus imperatoris, to replace Oberto. ==Regent of the kingdom==