Wells married Rebecca Reasteau. They had two children, but they died in childhood. His wife died in 1797. He married Sarah Griffith of
Rockville, Maryland, in 1798. They had six sons and five daughters, including Francis, John B., Rebecca and Sarah. His wife died in 1839. His daughter Rebecca married Philander Chase Jr., son of
Philander Chase. Wells was a senior warden at St. Paul's Episcopal Church. From 1798 to 1800, Wells built a manor house called "The Grove" in Steubenville. In 1830, due to bankruptcy, Wells sold "The Grove" to
Samuel Stokely. In 1832, Wells lived at a new home on his son Alexander's farm. Wells died on August 14, 1846. He was initially buried at a graveyard on 4th Street in Steubenville. He was re-buried at the family lot at Union Cemetery in Steubenville. ==Legacy==