Prior to her election, Karpoche worked for
Cheri DiNovo, her predecessor as MPP for Parkdale—High Park, first in DiNovo's constituency office and more recently as her executive assistant at
Queen's Park. She also served on the board of directors of the Canadian Tibetan Association of Ontario, and on the steering committee of the
International Tibet Network. In November 2024, she was nominated as the federal NDP candidate for Taiaiako'n—Parkdale—High Park.
Member of Provincial Parliament On September 14, 2017, the Parkdale—High Park NDP
riding association nominated Karpoche as the party's candidate in the
2018 general election. She won the election on June 7, 2018, and her party won the second most seats, becoming the
Official Opposition. Following her election, NDP leader
Andrea Horwath appointed Karpoche as deputy opposition whip and mental health and addictions critic. In a shadow cabinet shuffle on August 30, 2019, the deputy opposition whip was passed to
Doly Begum. In 2019, she was voted Toronto's Best Local Politician by
Toronto Star readers. She was voted Best MPP by
Now Magazine readers in 2019, 2020 and 2021. Karpoche was re-elected in the 2022 election with 53.97% of the popular vote. Following the selection of Interim Leader
Peter Tabuns, Karpoche retained her critic portfolio of early childhood development and children, and was assigned the additional portfolio of GTA issues. On July 15, 2022, it was announced that the Ontario NDP would be nominating Karpoche as a Deputy Speaker in the
43rd parliament. Karpoche introduced two
private member's bills in 2022;
Bill 25, Rent Stabilization Act and
Bill 55, Four-Day Work Week Act. Neither bill was voted on by the
Legislature before it was dissolved for the
2025 provincial election. As of August 11, 2024, she serves as the Official Opposition's critic for Affordability and for
GTA issues. In September 2024, Karpoche announced she would not seek re-election in the
2025 Ontario general election so that she could run in the
2025 Canadian federal election in the federal constituency of
Taiaiako'n—Parkdale—High Park. ==Electoral record==