The clinical significance of bilirubin glucuronide is involved in many conditions. Drugs that inhibit the activities of the components involved in bilirubin metabolism can give rise to accumulation of bilirubin in the blood.
Liver failure or hepatitis If it is the liver that cannot effectively transfer the indirect bilirubin into bilirubin glucuronide and further into bilirubin di-glucuronide, the consequence will be
hyperbilirubinemia or
intrahepatic (or hepatocellular) jaundice. These conditions are associated with either defective intracellular protein binding (for the second time) or disturbed secretion into the
bile canaliculi (
Dubin–Johnson syndrome).
Crigler Najjar disease In
Crigler Najjar disease, there is an inherited deficiency of
glucuronyl transferase resulting in high concentrations of unconjugated bilirubin appear in the plasma. Up to 8% to 11% neonates will develop
hyperbilirubinemia in the first week of their lives.
cancer mortality, or
colorectal cancer in general population, the potential benefits of the chemopreventive function of bilirubin and their causative relations haven't been proved. ==Notes==