MarketBiocon
Company Profile

Biocon

Biocon Limited is an Indian biopharmaceutical company based in Bengaluru, with U.S. headquarters in Bridgewater, New Jersey. The company was founded by Kiran Mazumdar-Shaw in 1978. The company manufactures generic active pharmaceutical ingredients (APIs) that are sold in approximately 120 countries, including the United States and Europe. It also manufactures novel biologics as well as biosimilar insulins and antibodies, which are sold in India as branded formulations. Biocon's biosimilar products are also sold in both bulk and formulation forms in several emerging markets.

History
Biocon was founded in 1978 with US$10,000 as the initial capital by a Kiran Mazumdar who was born to Gujarati parents in Bangaluru. In 1979, Biocon became the first Indian company to manufacture and export enzymes to the US and Europe. In 1989, Unilever acquired Biocon Biochemicals Ltd. in Ireland and merged it with its subsidiary Quest International. Biocon received US funding for proprietary technologies. In 2001, Biocon became the first Indian company to be approved by the USFDA for the manufacture of lovastatin; PlaFractor was granted a US 2001 and worldwide patent. In 2003, Biocon became the first company worldwide to develop human insulin on a pichia expression system. In 2006, BIOMAb EGFR, the first indigenously developed humanised monoclonal antibody for head-and-neck cancer, was launched, and APJ Abdul Kalam inaugurated India's largest biotech-hub, Biocon Park. In 2008, Biocon acquired a 70% stake in German pharmaceutical company AxiCorp GmbH. During 2009, a Syngene-Bristol Myers Squibb research facility was established in Bengaluru. Later in 2009, Mylan announced a strategic collaboration with Biocon to enter the global generic biologics market. In 2010, Biocon expanded to Malaysia, with a biopharmaceutical manufacturing and R&D facility established in Iskandar, Johor. In 2012, Abbott announced a collaboration with Syngene to open the first nutrition R&D center in India. During 2013, Biocon launched the biologic drug ALZUMAb to treat psoriasis. During 2014, Biocon launched the first biosimilar drug, CANMAb, to treat breast cancer. In 2015, Biocon launched a hepatitis-C drug in India under the brand name CIMIVIR-L. In 2016, Biocon became the first Indian company to launch a biosimilar insulin glargine pen in Japan. During 2016, Syngene set up an Amgen R&D center in Bangalore. In 2017, Biocon's Insugen became the first locally manufactured biosimilar product to be approved for sale by the Malaysian drug regulator. In 2017, USFDA approved Mylan-Biocon's biosimilar for the cancer drug Herceptin. During 2018, Biocon and Mylan received the European Commission's approval to market the biosimilar insulin glargine. During 2021, Biocon Biologics and Serum Institute of India formed a joint agreement to commercialise vaccines, biological drugs, and antibody therapies together. Another aspect of the deal involved Bicocon selling 15% of its biologics subsidiary to the Serum Institute of India, in return for Biocon gaining access to 100 million annual doses of vaccines for a 15-year period. ==Corporate governance==
Corporate governance
Biocon's CMD Kiran Mazumdar-Shaw joined Biocon in 1978. On 3 December 2019, Siddharth Mittal took over from Arun Chandavarkar, who retired as CEO and joint managing director of Biocon. In 2021, Hamacher resigned from her position, following differences with Kiran Mazumdar-Shaw. ==Subsidiaries==
Subsidiaries
Biocon Biologics , Bangalore Biocon Biologics is Biocon's biosimilar subsidiary. In 2021, Biocon and Viatris received approval to launch Semglee, an insulin glargine-yfgn injection, the first interchangble biosimilar for diabetes in the United States. In 2021, Biocon sold 15% of Biocon Biologics to Serum Institute of India for a valuation of $4.9 billion, for which Biocon will receive access to 100 million doses of vaccines per annum for 15 years. These vaccines will mainly be supplied from Serum Institute's upcoming vaccine facility in Pune, and Biocon will also have the commercialization rights of Serum Institute's vaccine portfolio, which includes the COVID-19 vaccine, for the international markets. Syngene International Ltd Established in 1993, Syngene International Limited is a contract research and development organization (CDMO). In the CDMO space, Syngene primarily focuses on research innovation and manufacturing services for their clients. The company has four divisions: drug discovery services, dedicated research centres, development devices and manufacturing. Syngene has been expanding its operations. Since 2020, the company has opened an R&D centre in Hyderabad, is building an API manufacturing facility in Mangalore, which was scheduled to be commissioned in 2022, and has expanded their R&D facility in Bangalore. Syngene also provides biologics CDMO services. In July 2022, Syngene signed a 10-year agreement with Zoetis to manufacture the drug substance for Librela (bedinvetmab), a first-in-class monoclonal antibody used for treating osteoarthritis in dogs. SynVent is Syngene's drug discovery and development platform for both small and large molecules. In September 2022, Biocon divested 5.4% of its shares in Syngene International. Clinigene Clinigene International Limited is a subsidiary of Syngene offering international pharmaceutical majors Phase I-IV clinical trials and studies for novel/generic molecules. NeoBiocon Incorporated in January 2008, NeoBiocon FZ LLC is a research and marketing pharmaceutical company based in Abu Dhabi. Biofusion Therapeutics Limited Biofusion Therapeutics Limited was incorporated in March 2021. It is 100% owned by Biocon. ==Strategic partnerships==
Strategic partnerships
Biocon and Amylin In 2009, Biocon and Amylin Pharmaceuticals of the United States entered into an agreement to develop, commercialise and manufacture a novel peptide therapeutic for the potential treatment of diabetes. Amylin provides expertise in peptide hormone development, particularly in the area of phybrid technology and metabolic disease therapeutics. Biocon will utilise its expertise in recombinant microbial expression and experience in preclinical and clinical development of diabetes products to manufacture the compound. ==Operations==
Operations
Biocon's manufacturing facilities are located at two sites in Bangalore. Biocon's R&D focuses on the entire drug development pathway – from process development to non-clinical and clinical research. Biocon offers 36 brands of products across the four therapeutic divisions of diabetology, nephrology, oncology, and cardiology. ==References==
tickerdossier.comtickerdossier.substack.com