Weiss began her career as a journalist, working for
Demokraten and then for
Information. She served as the deputy chairperson of the social democrats from 1994 to 1996 and first vice-chairperson of the Parliament from 1998 to 1999. She assumed various cabinet positions. Her first ministerial post was the minister of interior, and she served in the office from 1993 to 1997. She resigned from the post on 20 October, and
Thorkild Simonsen succeeded her in the post.{{cite journal|author=Jens Rydgren|title=Radical Right-wing Populism in Denmark and Sweden|journal=
The SAIS Review of International Affairs|date=Winter–Spring 2010
Activities When she was the interior minister Weiss delivered a bill in 1996, stating that a foreigner, who is guilty of drug-related crime, should be deported from Denmark.{{cite news|title=Report to the UN on Discrimination and Racism in Denmark|access-date=22 April 2013|work=The Torch ==Personal life and death==