Fuenlabrada (2011) Biyombo made his debut at age 18 in the
Spanish ACB League with
Fuenlabrada against
DKV Joventut on January 9, 2011, recording 5 points and 7 rebounds in just over 13 minutes of play. In Fuenlabrada's narrow defeat to
Real Madrid, he recorded 6 points and 3 blocks, one of them against former
Spanish League MVP and
Spanish national team player,
Felipe Reyes. On December 19, 2011, Biyombo signed a multi-year deal with the Bobcats. After averaging five points per game over his first two seasons with Charlotte, Biyombo's minutes and subsequent production dropped dramatically in 2013–14 as he fell out of favor with coach
Steve Clifford, as he averaged just 2.9 points in 13.9 minutes per game. The Bobcats changed their name to the
Hornets ahead of the
2014-15 season. While his forte in defense and rebounding did drop in 2013–14, Biyombo began the 2014–15 season in much better form despite missing seven out of the first eight games of the season largely due to the acquisition of
Jason Maxiell in the 2014 off-season. With the late-December injury to center
Al Jefferson, Biyombo was placed into the starting line-up. On June 30, 2015, the Hornets decided not to extend a qualifying offer to Biyombo, making him an unrestricted free agent.
Toronto Raptors (2015–2016) On July 18, 2015, Biyombo signed a two-year, $5.7 million contract with the
Toronto Raptors. On August 1, 2015, he played for Team Africa at the
2015 NBA Africa exhibition game. He made his debut for the Raptors in the team's season opener against the Indiana Pacers on October 28, recording 7 points and 5 rebounds in a 106–99 win. Biyombo started in 18 straight games between mid-November and late December while
Jonas Valančiūnas was recovering from a fractured hand. On December 17, he recorded 8 points, a then career-high 18 rebounds, and a career-high tying 7 blocks in a loss to the Charlotte Hornets. Five days later, he recorded 9 points and a then career-high 20 rebounds in a 103–99 win over the Dallas Mavericks. Biyombo returned to a bench role on December 30. He returned to the starting line-up in mid-March with Valančiūnas out injured again. On March 17, 2016, Biyombo scored a career-high 16 points and set a franchise record with 25 rebounds in guiding the Raptors to a 101–94 overtime win over the
Indiana Pacers. On March 30, he recorded seven points and six rebounds in a 105–97 win over the Atlanta Hawks, helping the Raptors record a 50-win season for the first time in franchise history. The Raptors finished the regular season as the second seed in the Eastern Conference with a 56–26 record. In the first round of the playoffs, the Raptors faced the seventh-seeded Indiana Pacers, and in a Game 5 win on April 26, Biyombo recorded 10 points and 16 rebounds off the bench to help the Raptors take a 3–2 series lead. The Raptors went on to win the series 4–3, moving on to the second round where they faced the Miami Heat. In Game 7 of the Raptors' series with the Heat, Biyombo recorded 17 points and 16 rebounds as a starter in a 116–89 win, helping the Raptors advance to the conference finals for the first time in franchise history. In Game 3 of the conference finals against the Cleveland Cavaliers, Biyombo set a Toronto playoff record with 26 rebounds, helping the Raptors cut the Cavaliers' advantage in the series to 2–1. The Raptors went on to lose the series in six games. After declining his $2.9 million player option for the 2016–17 season, Biyombo became an unrestricted free agent on June 7, 2016. Biyombo later revealed that he wished to re-sign with the Raptors, but with the re-signing of
DeMar DeRozan, the Raptors did not have the salary cap space to make it possible.
Orlando Magic (2016–2018) On July 7, 2016, Biyombo signed a four-year, $72 million contract with the
Orlando Magic. After exceeding the flagrant foul limit during the 2016 playoffs, Biyombo was forced to serve an NBA-mandated one-game suspension to begin the 2016–17 season. He made his debut for the Magic in the team's second game of the season on October 28, scoring two points in just under 23 minutes in a 108–82 loss to the
Detroit Pistons. On January 16, 2017, he scored a season-high 15 points against the
Denver Nuggets. He tied that mark on February 11, scoring 15 points against the
Dallas Mavericks. On March 5, he grabbed a season-high 15 rebounds against the
Washington Wizards. On January 1, 2018, Biyombo recorded 13 points and a season-high 17 rebounds in a 98–95 loss to the
Brooklyn Nets. On January 12, he scored a career-high 21 points in a 125–119 loss to the Washington Wizards. On April 4, he had 12 points, 12 rebounds and a career-high five assists in a 105–100 win over the
Dallas Mavericks.
Return to Charlotte (2018–2021) On July 7, 2018, Biyombo was traded back to the
Charlotte Hornets in a three-team deal. On January 5, 2019, he scored a season-high 16 points in a 123–110 loss to the
Denver Nuggets. On November 27, 2019, Biyombo recorded a season-high 19 points along with 9 rebounds and two blocks in a 102–101 win against the
Detroit Pistons. On December 16, 2019, he logged a season-high 17 rebounds along with 11 points and a block against the
Indiana Pacers. Biyombo re-signed with the Hornets on November 30, 2020. On February 5, 2021, he scored a season-high 13 points, along with four rebounds and one assist in 19 minutes against the
Utah Jazz. On April 13, he recorded a double-double of 10 points and 12 rebounds against the
Los Angeles Lakers. On May 1, he had a season-high five blocks off the bench against the
Detroit Pistons. Biyombo again scored 13 points on May 13, where he also recorded seven rebounds and one assist against the
Los Angeles Clippers.
Phoenix Suns (2022–2023) Biyombo became an unrestricted free agent after the
2020–21 season. He did not sign with any team throughout 2021 in part due to him grieving for the passing of his father, François. On January 1, 2022, he signed a 10-day contract with the
Phoenix Suns via the COVID-19 hardship exemption. On January 11, Biyombo signed for the rest of the season after showing off some very positive production during his 10-day contract. On January 17, Biyombo had 17 points and 14 rebounds. Five days later, on January 22, Biyombo recorded 21 points, 13 rebounds, and 5 assists coming off the bench. From January 26–30, Biyombo became a starter once again due to injuries to
Deandre Ayton and
JaVale McGee. In the 17 games Biyombo played from January to February 12, the Suns were undefeated. On July 5, 2022, the Suns re-signed Biyombo.
Memphis Grizzlies (2023–2024) On November 1, 2023, Biyombo signed with the
Memphis Grizzlies, but was waived on January 10, 2024.
Oklahoma City Thunder (2024) On February 10, 2024, Biyombo signed with the
Oklahoma City Thunder. On March 6, Biyombo unexpectedly collapsed to the floor on his team's sideline during a game against the
Portland Trail Blazers. He was eventually able to leave the court under his own power and was cleared of any serious medical condition.
San Antonio Spurs (2025) On February 9, 2025, Biyombo signed a 10-day contract with the
San Antonio Spurs. On February 21, Biyombo and the Spurs agreed to another 10-day contract. On March 3, the Spurs signed him to a contract for the remainder of the season. In 28 appearances (26 starts) for San Antonio, Biyombo averaged 5.1 points, 5.6 rebounds, and 1.1 assists. On September 15, 2025, Biyombo re-signed with the Spurs on a one-year contract. ==Personal life==