Deen and his brother
Jamie had their own show,
Road Tasted, which launched in July 2006. They eventually decided that they wanted to devote more time to their family restaurant in
Savannah, Georgia, the Lady & Sons, which they ran with their mother,
Paula, until it closed, on July 31, 2025. In January 2012, Deen debuted his own cooking show, ''
Not My Mama's Meals'', on the
Cooking Channel, in which he tweaks his mother's recipes to recreate them in a healthier manner. Deen also served as the host of the Food Network cooking competition series
Holiday Baking Championship and
Spring Baking Championship. He is also co-host of the
Cooking Channel series
Junk Food Flip. Deen has published several books, four of which are in collaboration with his brother. These include
The Deen Bros. Cookbook - Recipes From the Road (2007), ''Y'all Come Eat
(2008), Take it Easy
(2009), and Get Fired Up
(2011). In early 2013, he released his first solo book, From Mama's Table to Mine'', which became a No. 1 New York Times Bestseller. In April 2015, Deen and his brother began filming the TV show
Southern Fried Road Trip for the Food Network, "in search of the best local, handcrafted foods". Deen made his feature film debut in 2017, appearing in the movie
In Search of Liberty.{{cite web|last=Rayburn|first=Josh|title=Savannah-filmed, Bobby Deen-starring 'In Search of Liberty' debuts Aug. 9 ==Recognition==