; : :The protagonist who is a teenage high school girl whose name, Tsukushi, means "weed". She is thus the "weed" that will challenge the "Flower Four" or F4. Tsukushi is one of the very few students studying at Eitoku High School to come from a middle-class family. Her mother pushed her to join Eitoku because the children of her father's work colleagues all attend prestigious schools. Tsukushi is unhappy at Eitoku, but feels if she quietly exists for two years, she can survive it. However, after defending her friend who accidentally falls down a set of stairs and onto the leader of the F4, Tsukasa Domyoji, she, instead, receives a red card—a declaration of war. This officially marks her for future torment by the F4 and the rest of the student body. :However, unlike most of the F4's targets, Tsukushi retaliates by directly attacking Tsukasa. This unexpected retaliation and steadfast resistance to the hazing is one that he has never encountered from a target before, and falls in love with Tsukushi. Initially, Tsukushi hates all of the F4 except Rui Hanazawa, for whom she harbors romantic feelings. But, after Rui admits that he will never stop loving his childhood sweetheart Shizuka, Tsukushi slowly falls in love with Tsukasa and becomes friends with the F4. ; : :Tsukasa is the leader of the F4 group and the
heir to the large Domyoji Enterprises. He grew up with the rest of the F4 as his mother was always overseas, and his older sister relocated to Los Angeles after her marriage. His mother, in particular, is cold towards him, and wants to control his life for the sake of preserving the family name. :As the extremely hot-headed and volatile leader of the F4, Tsukasa uses his power to rule over the entire school. He uses an infamous red card and attaches it inside anyone's locker who has made the F4, particularly him, upset. A red card gives the entire student body at Eitoku free rein to bully, prank, and humiliate the receiver until they decide to leave the school. However, Tsukushi's declaration of war against the F4 after receiving the red card, retaliation against the student body and strong will, reminds Tsukasa of his beloved older sister, Tsubaki. He thus grows fond of Tsukushi, eventually falling madly in love with her. ; : :Rui is Tsukasa's best friend and Tsukushi's first romantic interest. He is generally quiet, distant, uninterested in people and is said to be
autistic. He only opens up to his close friends and the
model Shizuka Todo, to whom he was betrothed at birth. Rui admires Tsukushi's courage in standing up to Tsukasa and eventually begins to help her. After he comes back from France and witnessing Shizuka's marriage, Rui was very frustrated and slowly falls in love with Tsukushi. However, after learning that Tsukushi genuinely loves Tsukasa, Rui backs off. ; : :Sojirou is the biggest playboy of the F4. He is devoted to the practice of traditional Japanese tea ceremonies (which is his family's business). For the most part, he and Akira usually work to keep the peace within the group and following Tsukasa. ; : :Akira is arguably the most mature member of F4. His family is very powerful in the Japanese underground (in the manga they own a large trading company). He keeps his cool and rarely loses his temper, although when he does, even Domyoji has to run for the hills. He has a pair of young twin sisters who annoy him due to their intense affection for him. ; : :Yuuki is Tsukushi's childhood friend. The two work together at a
dango shop after school. Yuuki cares a lot about Tsukushi's feelings, and does not want anybody to hurt Tsukushi. Yuuki offers Tsukushi a lot of encouragement and advice about her situation with the F4. ; : :Shizuka is a rich heiress, a fashion model, and a childhood friend of the F4, particularly Rui. She was the first person who was able to get him to come out of his shell, and the two were inseparable for much of their childhood. She began a modeling career during her high school years, but at her twentieth birthday party she announces that she will give up her career as a model as well as her position as the Todou heiress to move to Paris and become a human rights lawyer. She was very kind toward Tsukushi, as she sees her as Rui's romantic interest. Rui initially accompanies Shizuka to Paris at Tsukushi's request, but their relationship suffers as Shizuka spends more and more time at work. Towards the end of the manga series, Rui tell's Tsukushi that what happened between him and Shizuka is completely over and thats okay with him, they're on good terms and are still friends. ; : :Kazuya is another one of Tsukushi's childhood friends. He enrolls at Eitoku after his family comes into money through some real-estate deals. The other students at Eitoku draw a sharp distinction between Kazuya's "
new money" and their "
old money". The F4, in particular, mention this difference fairly often and consider him to be a nuisance as the story progresses, and simply tolerate him because of Tsukushi's fondness for him. ; : :Makiko is one of Tsukushi's only friends at Eitoku in the beginning of the series. Tsukushi rescues her from inevitable torment after she collides with Domyouji on the stairs. Although she is forced to break off their friendship to prevent becoming a target of abuse, Makiko finds ways to help Tsukushi, sending her secret messages of encouragement or to warn her of impending danger. ; : :Sakurako was the target of bullying as a young child, particularly by the F4, because she was born "ugly". When she confessed her love to Domyoji, he traumatized her by making fun of her looks. She eventually moved to Germany because of her family's business, and underwent plastic surgery to end the bullying. Many years later, she returns to Eitoku, where no one recognizes her now attractive face. She plans to take revenge on the F4, and befriends Tsukushi (who is unaware of her history). When she hears of Domyoji's growing attraction to Tsukushi, she conspires with her friend Thomas to destroy her. ; : :Junpei is a
kōhai of Tsukushi's that saves her from being bullied after she gets back from her trip to Canada. He first appears as a nerdy boy, with glasses and an oblivious attitude. He is actually a famous model for a well-known magazine, hiding his identity in school through his glasses. Tsukushi sees him as the only other person at school who thinks the way she thinks after he says he only needs to endure two more years. Junpei's real motive is to lure Domyoji in order to take revenge for an injury his older brother endured. He uses Tsukushi as bait to lure Tsukasa to him and his friend, who are looking for vengeance after being humiliated by Tsukasa. ; : :Shigeru is the heiress of the Okawahara Corporation, and Tsukasa's fiance
for the arranged marriage created by his mother. Tsukasa neither likes nor wants to marry her, although she falls in love with him. She also befriends Tsukushi without knowing of her past relationship with Tsukasa. ; : :Tsubaki is Tsukasa's elder sister, and closest friend. Although she bullies him, he adores and trusts her more than anyone else, as she raised him in the absence of their parents. After she graduated from Eitoku, she dated a working class man, which led to her mother forcing them apart so that Tsubaki could marry a wealthier man. Although she has obtained a degree of happiness in her marriage, she often gets sad and travels home to Japan when her husband is busy overseas. She begs Tsukasa not to make the same mistake in love. She sees Tsukushi as a younger sister, and always helps with her relationship with Tsukasa. ; : :Kaede is Tsukasa's controlling mother and is the
chairwoman of Domyoji Enterprises. She is a powerful and feared businesswoman who does everything she can to end Tsukasa's relationship with Tsukushi. At one point, she tried to pay Tsukushi 50 million yen to get her to agree not to see Tsukasa again. However, Tsukushi's mother refused the money and poured salt onto Kaede's head because Kaede had insulted Tsukushi. Kaede then tried to force Tsukasa to marry Shigeru. When she found out that Tsukasa was going to break up with Shigeru, she became furious and forced Tsukasa to marry Shigeru quickly. When Shigeru and Tsukasa "marry", she witnesses Shigeru's true plan to set Tsukasa and Tsukushi up and even tries to stop it at first. But after knowing that Tsukushi truly cares about Tsukasa and everyone else, she accepts their relationship and eventual marriage. ==Media==