McCarthy's first major role was in the 1983 comedy
Class opposite
Jacqueline Bisset. He quickly returned to Hollywood in 1988 to star in several films, such as
Fresh Horses and
Kansas. He had another hit with the 1989 comedy film ''
Weekend at Bernie's''. He returned to Broadway to star in
Side Man, and the production won the 1999
Tony Award for Best Play. In 2003, McCarthy was set to guest star in two episodes of
Law & Order: Criminal Intent. Due to bad relations with actor
Vincent D'Onofrio, series creator
Dick Wolf decided against it. Wolf later stated, "Mr. McCarthy engaged in fractious behavior from the moment he walked on the set." McCarthy fired back in a statement of his own saying, "I was fired because I refused to allow a fellow actor to threaten me with physical violence, bully me and try to direct me." Despite this incident, he later guest starred in a 2007 episode of
Law & Order: Criminal Intent (with Chris Noth, not D'Onofrio). In 2004, he played Dr. Hook in
Kingdom Hospital. He appeared in five episodes of the 2005
NBC television series
E-Ring. In 2008, he starred in the NBC television series
Lipstick Jungle as billionaire Joe Bennett and had a minor role in
The Spiderwick Chronicles. McCarthy directed several episodes of the hit
CW television series
Gossip Girl, including "
Touch of Eva" in the fourth season. In 2010 and 2011, he appeared in the hit
USA show
White Collar. He returned to the series in the next season to direct the episode "
Neighborhood Watch". In 2015, he directed three episodes in Season 2 of the
NBC hit television show
The Blacklist starring
James Spader and
Megan Boone. In 2016, he starred in the short-lived
ABC drama
The Family. From 2020 to 2021, he had a recurring role in NBC's TV series
Good Girls. In 2022, McCarthy joined the cast of
The Resident as Ian Sullivan, a renowned pediatric surgeon and Cade's estranged father. ==Writing==