2007 Castillo played with the
Senior National Team that traveled to
Guadalajara, Spain for a friendly series. She then played the
2007 Women's Pan-American Volleyball Cup in
Colima, Mexico. Her team qualified for the
2008 FIVB World Grand Prix with a 3–2 victory in quarterfinals over Puerto Rico, and finally winning the competition's bronze medal with a 3–1 victory over the United States. Castillo then played in the
2007 Pan American Games held in Rio de Janeiro, Brazil. Her national team lost in the quarterfinals after falling to Peru and ending up in fifth place. Castillo played in August her first Worldwide competition by playing the annual
FIVB World Grand Prix in Tokyo, Japan then Hong Kong, China and finally Taipei, where her team won their first competition's match ranking in eleventh place overall. After that competition, she moved in September with her national Senior Team to
Winnipeg, Canada, playing the
NORCECA Championship. There she won the bronze medal. She then took part in the world cup in the
FIVB World Cup when the Dominican Republic was assigned with a wild card. Her country ranked ninth after winning only three matches during the competition. In the second half of December, Castillo played in Monterrey, Mexico the NORCECA Olympic Qualification Tournament; but her team fell 0–3 to Canada in the semifinals getting out of contention for the Olympic berth and later 2–3 to Puerto Rico in the Bronze medal match.
2008 She played for the Senior National Team at the
2008 Olympic Qualification Tournament in
Japan. There her team ended up in fourth place, and did not qualify for the
2008 Summer Olympics. She then played in July with her National Junior Team, winning the silver medal at the
2008 NORCECA Junior Continental Championship U-20, and was elected
Most Valuable Player, Best Libero, Best Digger and Best Receiver. Shortly afterwards Castillo claimed with her Senior Team the gold medal at the
2008 Women's Pan-American Volleyball Cup in
Mexico as a sixteen-year-old. Later that year her team won the silver medal at the
Final Four Cup, as she won the
Rising Star award.
2009 During the
Holy Week Sport Festival held in
Hato Mayor, Castillo played
Beach Volleyball (three) with Yenifer Calcaño and
Evelyn Carrera winning the Gold Medal of the event. She won with her Senior team the silver medal and the "Rising Star" award at the
2009 Pan-American Cup. In June 2009, at the
2010 World Championship NORCECA Qualification Pool H, at
Santiago de los Caballeros, Dominican Republic, she took the public ovation at the
Gran Arena del Cibao winning the
Best Digger, Best Receiver, Best Libero and
MVP awards. She then participated with her Junior National Team she won the silver medal at the
2009 U20 World Championship, She started the 2010 year winning the
Best Libero, Digger and Receiver awards at the
2010 Pan-American Cup, won by her home team playing in
Rosarito and
Tijuana. Two weeks after the Pan-Am cup, she won the silver medal and the "Best Libero, Digger and Receiver awards at the
2010 NORCECA Junior Continental Championship U-20. The Dominican Republic Olympic Committee selected Castillo as the
Dominican Republic Flag bearer for the
2010 Central American and Caribbean Games held at
Mayagüez, Puerto Rico, from July 17, 2010, to August 1, 2010. In the
volleyball tournament of the Regional Games, she won with her team the gold medal. She later played in
Chiapas,
Mexico winning the Best Libero and Best Receiver awards, along with the gold medal with her National Senior Team at the
2010 Final Four Cup. Castillo later participated in her first
Senior World Championship in Japan, finishing second in digs and Best Libero categories, and
being 17th with her national team. and earning the Best Libero award.
2011 The Puerto Rican team
Criollas de Caguas signed Brenda for the 2011 season, as her first international club experience, joining the Canadian
Stacey Gordon and Dominicans
Bethania de la Cruz and
Annerys Vargas. She replaced the
injured Yarimar Rosa. During the regular season, Brenda accumulated statistics that make her Best Libero and Best Digger, and crowned the season winning the Puerto Rico League Championship, sweeping the final series against the
Mets de Guaynabo. Castillo then played the
2011 Pan-American Cup being awarded with the
Best Libero and
Best Digger awards, also winning the silver medal with her national team. She then took part of the
2011 Junior World Championship held in Lima, Peru. She helped her Junior National team to reach the 5th place in the tournament. and she finished in seventh place among the Liberos.
2012 In the
Summer Olympics NORCECA qualification tournament played in May in
Tijuana,
Baja California,
Mexico, Castillo saw her team qualify for the
2012 Summer Olympics, winning the gold medal against the
Cuban team. She earned awards for the Best Receiver and Best Libero of the competition. Later, she would confessed, that she played the tournament being
pregnant and would not be able to play at the Olympic Games. But about one month later, the National Team doctor gynaecologist Albert Fiorinelli Milciades Camilo, announced that Castillo suffered a
spontaneous abortion after 19 weeks of pregnancy. Two days later, she predicted that she would start training in 15 days in order to get physically fit to play in the Summer Olympics. At the
Pan-American Cup held in
Ciudad Juárez,
Mexico, she returned to play with the National team, finishing with her team in the 4th place and winning the Best Libero, Best Digger and Best Receiver awards. after losing the quarterfinal match 3–0 against the
United States. Nonetheless, she managed to win the individual award of Best Libero of the competition. She would later recall, as of July 2016, that award as the peak moment of her career. In September, Castillo won the gold medal and the Best Digger award at the first
2012 U23 Pan-American Cup, played in
Callao,
Peru. In early November 2012, Castillo signed with the
Azerbaijani club
Rabita Baku to play the
Azerbaijan Super League and the
CEV Champions League. Her goal was to achieve the league championship, even when she was playing without any knowledge of the
Azerbaijani language.
2013 As one of the 15 women awarded by the Dominican Republic Olympic Committee in her sport, Castillo won the 2012 Volleyball Player of the Year. Castillo was one of the candidates for the top prize, the Dominican Republic Athlete of the year, along with
Félix Sánchez,
Luguelín Santos,
Yamilet Peña and
Aumi Guerra. Castillo was also considered by the volleyball portal Volleyball.it among the candidates for the 2012 Globe Awards prize. She managed to survive Brazilian
Fabiana de Oliveira in the semifinal round, but she lost the final round to Italian Enrica Merlo 55% to 45%. Castillo played the
2012–13 CEV Champions League Final Four held in
Istanbul,
Turkey. Her team defeated the Italian club
Unendo Busto Arsizio 3–2 in the semifinals, but lost 3–0 in the championship match to the Turkish
VakıfBank. In April, Castillo's club, Rabita Baku claimed the Azerbaijan Super League Championship ahead of
Igtisadchi Baku and
Azerrail Baku, three weeks before the end of the season to win their sixth title in a row. She won the league's Best Libero award. She then played the
28th Montreux Volley Masters held in
Montreux,
Switzerland, after the invitation received by her National Team for the first time since 2003. Castillo's team won the Bronze Medal defeating Italy 3–1 after dropping the semifinals 0–3 from Brazil. Soon after this tournament, the Dominican Republic National Federation announced the Castillo's separation from the National Team due to erratic behavior and indiscipline. She would later apologize for her previous behavior and promised to change her attitude, being then readmitted in the national team just in time to take part in the
2013 FIVB World Grand Prix. posting a 3.69 digs per set average, topping all the diggers in the preliminary round. Castillo played in late September the
NORCECA Continental Championship, winning the silver medal and the Best Digger award. Castillo played with her national team at the
U23 World Championship, helping her team to win its pool with a 4–1 record. They later had a 3–0 win over the USA team in the semifinals before falling 0–3 to China in the final match. She finished the tournament statistics as the best digger and was awarded Best Libero.
2014 In January, Castillo was selected by the volleyball specialized website Volleywood for the
2013 My Volleywood Idol voting, advancing to the second round but, could not make a final four spot. After her Azeri club
Rabita Baku won the right to host the
2013–14 CEV Champions League Final Four, Castillo's club won the Bronze medal after falling 0–3 to the Russian
Dinamo Kazan in the semifinals, but defeating 3–0 to the Turkish
Eczacıbaşı VitrA Istanbul in the third place match. She was awarded tournament's Best Libero. She later commented that she felt lucky for playing another year with Rabita Baku and dedicated the club's recent triumph to their fans. This new accolade helped Castillo's popularity to grow in her home country, the Dominican Republic, there she is known as one of the most popular athletes. Rabita Baku, claimed their sixth title championship by winning the
2013–14 Azerbaijani Super League 3–0 to
Azeryol Baku and Castillo won the Best Libero individual award. The Dominican Republic head coach gave Castillo a little participation during the
2014 FIVB World Championship NORCECA qualification tournament held in La Romana, Dominican Republic, even when the
audience claimed for her appearance. Nonetheless, she helped her team to reach a berth to the 2014 World Championship in late May. Later in Mexico City, Mexico, Castillo help her national team to clinch the
2014 Pan American Cup championship and the 2015 Grand Prix berth. For her performance during the tournament, Castillo won the Most Valuable Player, Best Libero, Best Digger and Best Receiver. Castillo played the
FIVB World Grand Prix, being one of the favorites from the
attendants during the first week of the competition in
Sassari, Italy, resulting in many people
waiting in line for Castillo's
autograph and pictures. After winning just one match during the Group 1, the Dominican Republic finished in 12th and last place. Nonetheless, With a 3.85 digs per set, Castillo ranked first among her Group. Hoping to reach a late stage in the
World Championship held in Italy, Castillo helped her national team to start the competition undefeated 5–0 after winning over the home team 3–2. She ranked third in defense after the Pool A round robin competition. After a 7–2 start, her team qualified for the first time to the World Championship third round besides losing 2–3 to China, but being unable to reach a semifinal spot after losing their two third round matches 2–3 to China and 0–3 to Brazil. Ultimately Castillo's national team ended up in fifth place. Castillo returned to Rabita with the ambition of repeating the league championship and later announced a three years deal until 2017 with her Azerbaijani club, After her comments that being favorite make them work harder, she helped her national team to win their fourth consecutive gold medal. Winning the best digger, receiver and libero awards make her also win the tournament's Most Valuable Player.
2015 Because of the Dominican Republic Olympic Committee favoured the individual athletes, Castillo was not taken into account for the 2014 Athlete of the Year award besides of her notable 2014 year results. But she was selected by the Dominican Republic Guild of Sport Writers among the 2014 top athletes, along with boxer
Juan Carlos Payano,
Major League Baseball pitcher Johnny Cueto and the later top awarded, the tennis player
Víctor Estrella Burgos. Nonetheless, Castillo was selected volleyball player of the year. but the team were in the middle of a financial crisis and they then lost 0–3 to Dinamo Kazan despite their good reception and defense, and lost 2–3 to
Chemik Police in the last Champions League season match. After ranking fourth in their pool A, After the pool play, Castillo was chosen among the magnificent 7 weeks all-star team. they missed the qualification to playoffs and were relegated to the
CEV Cup and paired with Béziers Volley Rabita defeated
Béziers Volley 3–1 and 3–0 in the return match, and for the second time, they make it to the Cup semifinals. In the semifinals they faced the Russian club
Dinamo Krasnodar. But Rabita lost 1–3 in Russia and then lost 0–3 at Baku finishing their CEV Cup season in third place. Rabita Baku ultimately faced
Lokomotiv Baku in the Azerbaijani League final series, winning 3–1 the final series first match and again 3–1 in the second reaching Rabita's local league eight title and she won the league's Best Libero and Best Digger awards. Castillo later participated in the
2015 Montreux Volley Masters, but her national team lost the fifth place match 1–3 to Germany. Soon after that, she took part of the
NORCECA Champions Cup, taking home the gold medal and the qualification for the
2015 FIVB World Cup and also winning the Best Digger award. Castillo played the
Pan-American Cup in Peru, winning the silver medal when her national team lost to the United States 0–3 in the championship match. In spite of that, they qualified to the 2016 FIVB Grand Prix As part of a historic Dominican Republic delegation to the
2015 Pan American Games, she won with her national team the bronze medal after losing to the United States in the semifinals and defeated 3–1 the Puerto Rico national team. In the World Cup, Castillo also won the best libero award, while her team finished in the seventh place from twelve with a 5–6 record. Later that month, the Azerbaijani club
Lokomotiv Baku announced that Castillo have signed a one-year contract with them.
2016 After a 3–0 matches sweep over
Azeryol Baku, Castillo helped
Lokomotiv Baku to win the
2015–16 Azerbaijan Super League bronze medal and she was awarded Best Digger. She joined her national team, competing in the
World Olympic qualification tournament, were her team finished in sixth place from eighth teams, not qualifying for the
2016 Summer Olympics. Even though, her performance made her recipient of the Best Libero individual award. After that, she was selected Best Libero by the social media poll conducted by the specialized portal, World of Volley. She received 9,654 votes to lead the liberos contest. After receive a special salute for that accomplishment from the Women's and Sports commissioner of the Dominican Republic Olympic Committee
Dulce Piña, she was sidelined from her national team who won the gold in the
World Grand Prix Group II along with Prisilla Rivera to give them a rest. But her coach callEd her for the
Pan-American Cup played in home soil. Her team performed with 5–0 in the pool play before defeating Cuba 3–0 and finally to Puerto Rico once again, this time 3–2 to win the gold medal and a berth for the
2017 FIVB World Grand Prix. Castillo was awarded Best Digger, Receiver and Libero. Nonetheless, she expressed that she does not play for the awards, that they come for the strength invested for playing for her native country, Castillo signed with the Brazilian club Genter Vôlei Bauru for the 2016/2017 season.
2017 Genter Vôlei Bauru reached for the first time a
Brazilian Superliga quarterfinals berth, but they were defeated by
Minas 0–2 in the
best-of-three playoff. After losing the first match 0–3, Castillo tattooed the
John 3:16 Bible verse in one of her arms saying that these passage guided her life. However, Castillo was chosen among the tournament's best players, winning the Best Digger individual award, after she spent the season leading those statistics. She thanked God and expressed the satisfaction for being among the best of the league and described the accomplishment of playing with teamwork, helping her teammates in every match. and her national team finished the first round in the Netherlands with a 2–1 mark, But on the way to the second leg in Russia, making a stop in Warsaw, their
LOT Polish Airlines flight check found
Marianne Fersola,
Niverka Marte and Castillo's passports full and could not be stamped anywhere refusing to board them and the whole team decided to stay together. After finally arriving in Russia, the team was overall ranked eight after losing two matches from three played in the second round and Castillo was among the All-Star team from that Russian leg and was leading the WGP Group 1 digs with 3.64 digs per set. The
Russian police raided the Dominican team hotel suspecting involvement in
white-slave traffic from Latin-American to Russia and Castillo was jailed for two days. But she was detained in the airport along with
human trafficking involved people; her Russian
travel visa expired on July 15, two days before she tried to leave the country on July 17 The Dominican team finally ranked eight after losing two matches in the Thai round, not qualifying for the final round. She took part in the
NORCECA 2018 FIVB World Championship qualification tournament in Santo Domingo were her national team won the qualification and the World Championship berth, with Castillo winning the tournament's Most Valuable Player, Best Libero, Best Digger and Best Receiver awards.
2018 Castillo played the 2018 Dominican Republic Superior Volleyball League from the National District, playing with Cristo Rey and winning the tournament's silver medal when her team lost 1–3 to Caribeñas VC. She won the Best Libero, Best Digger and Best Receiver awards. At the
2018 Central American and Caribbean Games, Castillo won with her team the gold medal and the Best Libero and Best Digger individual awards. In the inaugural
Nations League her national team performed 3–12 ranking in the fourteenth place. Her team lost 2–3 in the final match of the
Pan-American Cup, winning the silver medal. She was awarded the Best Libero, Best Digger and Best Receiver. Castillo played the
World Championship in Japan, her team was 3–2 in the first round and 5–4 after the second round and finishing in ninth place when they could not qualify for the third round.
2021 Castillo won with her national team the
Pan-American Cup and she was awarded Best Libero, Best Digger and Best Receiver.
2024 She competed in the
Summer Olympics representing the Dominican Republic. ==Clubs==