After redshirting his first year at Michigan State in 2015, Lewerke appeared in four games and made two starts as a redshirt freshman in 2016. His season ended in October after suffering a broken
tibia after being tackled by
Jabrill Peppers in a game against
Michigan. He finished the season completing 31 of his 57 passing attempts for 381 yards, including two touchdowns and an interception. Lewerke entered the 2017 season as the starting quarterback for the team. He finished his 2017 redshirt sophomore season with 246 completions out of 417 passing attempts, 2793 total yards, 20 touchdowns, and 9 interceptions . Lewerke and the Spartans, who were ranked #19 at the time, also went on to beat
Washington State, the #21 ranked team at the time, 42–17 in the 2017 Holiday Bowl, in which Lewerke earned the Offensive MVP award. The Spartans finished the season 10–3, with a final ranking of #15 in the AP poll. In his junior season in 2018, Lewerke completed 189 out of his 339 passing attempts, threw for 2,040 yards and 8 touchdowns, and threw 11 interceptions. He also ran 90 times for 184 yards and 2 touchdowns, and was sacked 19 times. This gave him a 54.3 completion percentage and a passer rating of 106.1. That season, the Spartans went 7–6 overall, and 5–4 in the
Big Ten Conference. The Spartans also made an appearance in the
2018 Redbox Bowl, losing 7–6 to the
Oregon Ducks. In his senior season in 2019, Lewerke completed 234 out of his 399 passing attempts, threw for 2,759 yards and 16 touchdowns, and threw 12 interceptions. He also ran 100 times for 317 yards and 2 touchdowns, and was sacked 17 times. He had a 58.6 completion percentage for the season and a passer rating of 124.0. That season, the Spartans went 7–6 overall, and 4–5 in the
Big Ten Conference. The Spartans also made an appearance in the
2019 Pinstripe Bowl, winning 27–21 over the
Wake Forest Demon Deacons, in which Lewerke won the MVP award. During this game, Lewerke surpassed former quarterback
Connor Cook to become the school's all-time leader in total yards from scrimmage. ==Professional career==